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Merck
CN

840042C

Avanti

Liver PI

Avanti Research™ - A Croda Brand

Synonym(s):

L-α-phosphatidylinositol (Liver, Bovine) (sodium salt)

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About This Item

CAS Number:
383907-33-3
NACRES:
NA.25
UNSPSC Code:
12352211

Key Documents

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Product Name

Liver PI, Avanti Research™ - A Croda Brand

InChI

1S/C47H83O13P.Na/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)59-39(38-58-61(55,56)60-47-45(53)43(51)42(50)44(52)46(47)54)37-57-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2;/h11,13,17,19,22,24,28,30,39,42-47,50-54H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3,(H,55,56);/q;+1/p-1/b13-11-,19-17-,24-22-,30-28-;/t39-,42?,43-,44?,45?,46?,47-;/m1./s1

InChI key

NHSOICFDOXKHEC-ZGISKSNKSA-M

SMILES string

O[C@H]1[C@@H]([C@H](O)[C@H](O)[C@@H](O)[C@@H]1O)OP([O-])(OC[C@@]([H])(COC(CCCCCCCCCCCCCCCCC)=O)OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)=O.[Na+]

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (840042C-10mg)
pkg of 1 × 2.5 mL (840042C-25mg)
pkg of 1 × 4 mL (840042C-100mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

10 mg/mL (840042C-10mg)
10 mg/mL (840042C-25mg)
25 mg/mL (840042C-100mg)

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

Application

Liver PI has been used for the preparation of liposomes.

General description

Liver PI is a natural phosphatidylinositol. Phosphatidylinositol (PI) is a phosphoglyceride, that has an inositol head group. It is a vital phospholipid component of the plasma membrane.

Packaging

5 mL Clear Glass Sealed Ampule (840042C-100mg)
5 mL Clear Glass Sealed Ampule (840042C-10mg)
5 mL Clear Glass Sealed Ampule (840042C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

危险化学品
易制毒化学品（2类）
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Molecular Mechanisms Of Drug Action (2000)
Cell Biology (2007)
Determination of VPS34/PIK3C3 Activity in vitro Utilising 32P-gammaATP
Munson MJ and Ganley IG
Bio-protocol, 6(16) (2016)
Ruzica Bago et al.
The Biochemical journal, 463(3), 413-427 (2014-09-02)
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a subset of proteins possessing PtdIns(3)P-binding PX (phox homology) and
Eric S Melby et al.
Langmuir : the ACS journal of surfaces and colloids, 34(36), 10793-10805 (2018-08-14)
Molecular understanding of the impact of nanomaterials on cell membranes is critical for the prediction of effects that span environmental exposures to nanoenabled therapies. Experimental and computational studies employing phospholipid bilayers as model systems for membranes have yielded important insights
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