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840035P

Avanti

18:1 PS (DOPS)

Name: 18:1 PS (DOPS)
Brand: AVANTI

Avanti Research^™ - A Croda Brand

Synonym(s):

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine (sodium salt); DOPS; PS(18:1(9Z)/18:1(9Z))

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About This Item

Empirical Formula (Hill Notation):

C₄₂H₇₇NO₁₀PNa

CAS Number:

90693-88-2

Molecular Weight:

810.03

UNSPSC Code:

51191904

NACRES:

NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (840035P-10mg)
pkg of 2 × 100 mg (840035P-200mg)
pkg of 5 × 100 mg (840035P-500mg)
pkg of 1 × 25 mg (840035P-25mg)

manufacturer/tradename

Avanti Research^™ - A Croda Brand

solubility

soluble (Insoluble in ethanol and DMSO, soluble in Chloroform:Methanol:Water (65:25:4) at 5mg/mL)

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]

InChI

1S/C42H78NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h17-20,38-39H,3-16,21-37,43H2,1-2H3,(H,46,47)(H,48,49);/q;+1/p-1/b19-17-,20-18-;/t38-,39+;/m1./s1

InChI key

KPHZNDUWYZIXFY-YORIBCANSA-M

General description

DOPS is an excellent substitute for the naturally occurring Brain PS. It has similar physical properties and is more stable to oxidation. DOPS has been used, along with DOPC and DOPE, in lipid mixtures to mimic platelet membranes for coagulation studies.

Phosphoserine/phosphatidylserine (PS) is an endogenous phospholipid, that is found in all polyanionic macromolecules.

Application

18:1 PS (DOPS) has been used:

in liposomes (multi-lamellar vesicles) preparation
as a component in incubation buffer to measure exosomes associated procoagulant activity
in the preparation of lipid vesicles

Biochem/physiol Actions

Phosphoserine (PS) can be used as a template for the recognition of cancer antigen 125 (CA 125). It is very essential for healthy nerve cell membranes and myelin. Exogenous PS can be actively absorbed in humans. It has the ability to cross the blood-brain barrier. It plays a key role in the formation of short-term memory, the consolidation of long-term memory, the ability to create new memories and several other cognitive activities. It actively participates in the locomotor functions, like rapid reactions and reflexes.

Packaging

5 mL Clear Glass Sealed Ampule (840035P-10mg)

5 mL Clear Glass Sealed Ampule (840035P-200mg)

5 mL Clear Glass Sealed Ampule (840035P-25mg)

5 mL Clear Glass Sealed Ampule (840035P-500mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Product No.

Description

Pricing

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Proteomics profiling of plasma exosomes in epithelial ovarian cancer: A potential role in the coagulation cascade, diagnosis and prognosis

Zhang W, et al.

International journal of oncology, 54(5), 1719-1733 (2019)

Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-gamma

Pahl JHW, et al.

Journal of Experimental & Clinical Cancer Research, 33(1), 27-27 (2014)

Low-pH-Induced Lamellar to Bicontinuous Primitive Cubic Phase Transition in Dioleoylphosphatidylserine/Monoolein Membranes.

Toshihiko Oka et al.

Langmuir : the ACS journal of surfaces and colloids, 33(43), 12487-12496 (2017-10-03)

Electrostatic interactions (EIs) play important roles in the structure and stability of inverse bicontinuous cubic (QII) phases of lipid membranes. We examined the effect of pH on the phase of dioleoylphosphatidylserine (DOPS)/monoolein (MO) membranes at low ionic strengths using small-angle

Interfacial Forces Dictate the Pathway of Phospholipid Vesicle Adsorption onto Silicon Dioxide Surfaces.

Kabir H Biswas et al.

Langmuir : the ACS journal of surfaces and colloids, 34(4), 1775-1782 (2017-12-28)

The pathway of vesicle adsorption onto a solid support depends on the material composition of the underlying support, and there is significant interest in developing material-independent strategies to modulate the spectrum of vesicle-substrate interactions on a particular surface. Herein, using

Membrane Reconstitution of Monoamine Oxidase Enzymes on Supported Lipid Bilayers.

Liulin Wang et al.

Langmuir : the ACS journal of surfaces and colloids, 34(36), 10764-10773 (2018-07-28)

Monoamine oxidase A and B (MAO-A and B) are mitochondrial outer membrane enzymes that are implicated in a number of human diseases, and the pharmacological inhibition of these enzymes is a promising therapeutic strategy to alleviate disease symptoms. It has

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Documents

18:1 PS (DOPS)

Avanti Research™ - A Croda Brand

About This Item

Properties

Assay

form

packaging

manufacturer/tradename

solubility

lipid type

shipped in

storage temp.

SMILES string

InChI

InChI key

Description

General description

Application

Biochem/physiol Actions

Packaging

Legal Information

Related Products

also commonly purchased with this product

Safety Information

Storage Class Code

WGK

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Peer Reviewed Papers

Technical Service

Avanti Research^™ - A Croda Brand