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840033P

Avanti

14:0 PS

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-ditetradecanoyl-sn-glycero-3-phospho-L-serine (sodium salt); DMPS; PS(14:0/14:0)

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About This Item

Empirical Formula (Hill Notation):
C34H65NO10PNa
CAS Number:
105405-50-3
Molecular Weight:
701.84
UNSPSC Code:
51191904
NACRES:
NA.25

description

1,2-dimyristoyl-sn-glycero-3-phospho-L-serine (sodium salt)

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (840033P-10mg)
pkg of 1 × 200 mg (840033P-200mg)
pkg of 1 × 25 mg (840033P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C34H66NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-32(36)42-27-30(28-43-46(40,41)44-29-31(35)34(38)39)45-33(37)26-24-22-20-18-16-14-12-10-8-6-4-2;/h30-31H,3-29,35H2,1-2H3,(H,38,39)(H,40,41);/q;+1/p-1/t30-,31+;/m1./s1

InChI key

QSHQBWBFNCFHLO-MFABWLECSA-M

General description

Phosphatidylserine (PS) is a retinal phospholipid, which carries long-chain highly unsaturated fatty acyl groups.

Application

14:0 PS may be used as an internal standard for spiking serum lipid samples for liquid chromatography-mass spectroscopy analysis and as a component in the phospholipid monolayer to mimic model cancer cell membrane for the anticancer drug doxorubicin (DOx) interaction studies. It has been used in lipid binding assay to assess the binding of monoclonal antibodies (mAbs).

Biochem/physiol Actions

Phosphatidylserine (PS) helps to activate protein kinase C (PKC). It may possess anti-inflammatory properties. PS is also known to participate in tyrosine hydroxylase activation. It is also involved in the uptake of Ca2+ and glucose.

Packaging

5 mL Amber Glass Screw Cap Vial (840033P-10mg)
5 mL Amber Glass Screw Cap Vial (840033P-200mg)
5 mL Amber Glass Screw Cap Vial (840033P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Product No.
Description
Pricing

830845P

14:0 PA, 1,2-dimyristoyl-sn-glycero-3-phosphate (sodium salt), powder

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18:1 PS (DOPS), Avanti Research™ - A Croda Brand

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14:0 PC (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine, powder

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12:0 SM (d18:1/12:0), Avanti Research™ - A Croda Brand 860583P, powder

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cognitive Effects of Nutraceuticals
Nutraceuticals, 29-48 (2016)
BIOSYNTHESIS OF MEMBRANE LIPIDS IN THE RETINA: SUBCELLULAR DISTRIBUTION AND PROPRANOLOL ACTION ON PHOSPHATIDIC ACID, PHOSPHATIDYLSERINE AND PHOSPHATIDYLETHANOLAMINE
Neurochemistry of the Retina, 17-28 (1980)
Effect of pH on the interactions of doxorubicin with charged lipid monolayers containing 1,2-dimyristoyl-sn-glycero-3-phospho-l-serine - An important component of cancer cell membranes
Matyszewska D, et al.
Electrochimica Acta, 280, 229-237 (2018)
B Fichtl et al.
Langmuir : the ACS journal of surfaces and colloids, 34(16), 4914-4919 (2018-04-04)
Currently, biological signaling is envisaged as a combination of activation and movement, triggered by local molecular interactions and molecular diffusion, respectively. However, here, we suggest that other fundamental physical mechanisms might play an at least equally important role. We have
Charles F DeLisle et al.
The FEBS journal (2020-02-23)
Pro-islet amyloid polypeptide (proIAPP) is the prohormone precursor molecule to IAPP, also known as amylin. IAPP is a calcitonin family peptide hormone that is cosecreted with insulin, and largely responsible for hunger satiation and metabolic homeostasis. Amyloid plaques containing mixtures
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