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840012C

Avanti

Heart CA

Avanti Research™ - A Croda Brand

Synonym(s):

Cardiolipin (Heart, Bovine) (sodium salt)

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About This Item

CAS Number:
383907-10-6
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2 mL (840012C-50mg)
pkg of 1 × 2.5 mL (840012C-25mg)
pkg of 1 × 4 mL (840012C-100mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

10 mg/mL (840012C-25mg)
25 mg/mL (840012C-100mg)
25 mg/mL (840012C-50mg)

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C81H142O17P2.2Na/c1-5-9-13-17-21-25-29-33-37-41-45-49-53-57-61-65-78(83)91-71-76(97-80(85)67-63-59-55-51-47-43-39-35-31-27-23-19-15-11-7-3)73-95-99(87,88)93-69-75(82)70-94-100(89,90)96-74-77(98-81(86)68-64-60-56-52-48-44-40-36-32-28-24-20-16-12-8-4)72-92-79(84)66-62-58-54-50-46-42-38-34-30-26-22-18-14-10-6-2;;/h21-28,33-40,75-77,82H,5-20,29-32,41-74H2,1-4H3,(H,87,88)(H,89,90);;/q;2*+1/p-2/b25-21-,26-22-,27-23-,28-24-,37-33-,38-34-,39-35-,40-36-;;/t76-,77-;;/m1../s1

InChI key

ZGSPNIOCEDOHGS-LBOJVHLDSA-L

General description

Cardiolipin is a phospholipid found in the inner membrane of the mitochondria. It is synthesized from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. It consists of two phosphatidyl residues, which are linked by a glycerol group.

Application

Heart CA has been used in the Mycobacterium lipid extraction and in β- Hexosaminidase release and calcium mobilization assays. It maybe used for liposome synthesis. It may also be used as a lipid standard for the in situ analysis and characterization of cardiolipins.

Biochem/physiol Actions

Cardiolipin is involved in maintaining the structure and function of the mitochondria. It also serves as a co-factor for stimulating mitochondrial enzymes and mediates mitochondrial apoptosis. Cardiolipin is associated with the oxidative phosphorylation system for the adenine triphosphate (ATP) synthesis in the inner membrane of the mitochondria. Deficiency of cardiolipin is associated with variation of mitochondrial membrane structure and function. It is also associated with Barth syndrome.

Packaging

5 mL Clear Glass Sealed Ampule (840012C-100mg)
5 mL Clear Glass Sealed Ampule (840012C-25mg)
5 mL Clear Glass Sealed Ampule (840012C-50mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

易制毒化学品（2类）
危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cardiolipin stabilizes respiratory chain supercomplexes
Pfeiffer K, et al.
The Journal of Biological Chemistry, 278(52), 52873-52880 (2003)
Cardiolipin, the heart of mitochondrial metabolism
Houtkooper R H and Vaz F M
Cellular and Molecular Life Sciences, 65(16), 2493-2506 (2008)
Direct MALDI-MS analysis of cardiolipin from rat organs sections
Wang Hay-Yan J, et al.
Journal of the American Society For Mass Spectrometry, 18(3), 567-577 (2007)
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification
Cole NB, et al.
Experimental Cell Research, 314(10), 2076-2089 (2008)
Vilius Kurauskas et al.
The journal of physical chemistry letters, 9(5), 933-938 (2018-02-06)
Characterizing the structure of membrane proteins (MPs) generally requires extraction from their native environment, most commonly with detergents. Yet, the physicochemical properties of detergent micelles and lipid bilayers differ markedly and could alter the structural organization of MPs, albeit without
View All Related Papers

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