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830842P

Avanti

08:0 PA

1,2-dioctanoyl-sn-glycero-3-phosphate (sodium salt), powder

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Synonym(s):
PA(8:0/8:0)
Empirical Formula (Hill Notation):
C19H36O8PNa
CAS Number:
321883-54-9
Molecular Weight:
446.45
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (830842P-10mg)
pkg of 1 × 25 mg (830842P-25mg)

manufacturer/tradename

Avanti Polar Lipids 830842P

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[Na+]

InChI

1S/C19H37O8P.Na/c1-3-5-7-9-11-13-18(20)25-15-17(16-26-28(22,23)24)27-19(21)14-12-10-8-6-4-2;/h17H,3-16H2,1-2H3,(H2,22,23,24);/q;+1/p-1/t17-;/m1./s1

InChI key

ZNDNSOYDPUTHKQ-UNTBIKODSA-M

General description

Phosphatidic acid is obtained from glycerophospholipid with the help of phospholipase D. 08:0 PA/1,2-dioctanoyl-sn-glycero-3-phosphate (C8-PA) is an mammalian target of rapamycin (mTOR) activator.

Application

08:0 PA may be used to activate p-mTOR in order to assess whether the observed apoptotic effect of histone deacetylase inhibitors (HDACIs) is related to mammalian target of rapamycin (mTOR) pathway signaling.

Biochem/physiol Actions

Phosphatidic acid might serve as a modulator of phagocyte respiratory burst. It also acts as a precursor of diacylglycerol and lysophosphatidic acid. 08:0 PA/C8-PA has the ability to affect the phosphorylation of mammalian target of rapamycin (mTOR) and the viability of gallbladder carcinoma cells, that are treated with histone deacetylase inhibitors (HDACIs).

Packaging

5 mL Clear Glass Sealed Ampule (830842P-10mg)
5 mL Clear Glass Sealed Ampule (830842P-25mg)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Histone deacetylase inhibitors inhibit the proliferation of gallbladder carcinoma cells by suppressing AKT/mTOR signaling
Zhang P, et al.
Testing, 10(8), e0136193-e0136193 (2015)
A Yalcin et al.
Oncogene, 29(1), 139-149 (2009-10-27)
Choline is an essential anabolic substrate for the synthesis of phospholipids. Choline kinase phosphorylates choline to phosphocholine that serves as a precursor for the production of phosphatidylcholine, the major phospholipid constituent of membranes and substrate for the synthesis of lipid
Hae-In Song et al.
Scientific reports, 6, 36968-36968 (2016-11-23)
Phospholipase D1 (PLD1) plays a known role in several differentiation processes, but its role in adipogenic differentiation remains unknown. In the present study, we identified PLD1 as a negative regulator of adipogenic differentiation. We showed that PLD activity was downregulated
Glycerolipids in signal transduction
Lambeth JD and Ryu SH
New comprehensive biochemistry, 31, 237-255 (1996)
Jie Li et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(14), 3843-3855 (2020-04-29)
Although platinum compounds are the first-line treatment for ovarian cancer, the majority of patients relapse and develop resistance to treatment. However, the mechanism underlying resistance is unclear. The goal of our study is to decipher the mechanism by which a

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