810610P
Avanti
4-palmitamido-TEMPO
N-tempoyl palmitamide, powder
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4-Palmitamido-2,2,6,6-tetramethylpiperidine-1-oxyl; 2,2,6,6-Tetramethyl-4-[(1-oxohexadecyl)amino]-1-piperidinyloxy; 2,2,6,6-tetramethyl-4-palmitamidopiperidinooxy; 2,2,6,6-Tetramethylpalmitoylamidopiperidine-1-oxyl; 4-(Palmitylimino)-2,2,6,6-tetramethyl-1
C25H49N2O2
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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810610P-1mg)
manufacturer/tradename
Avanti Polar Lipids 810610P
lipid type
ESR probes
shipped in
dry ice
storage temp.
−20°C
General description
4-palmitamido-TEMPO/N-tempoyl-palmitamide is a spin label, that is present in the polar head-group region of the membrane.
This amphiphilic compound binds strongly to membranes by virture of its long hydrocarbon chain, but the polarity of the amide linkage is expected to localize the nitroxide function in the aqueous phase adjacent to the membrane surface. The location of the nitroxide function allows one to investigate electrostatic potentials and lipid-protein interactions at the membrane surface.
Application
4-palmitamido-TEMPO/N-tempoyl palmitamide (N-TP) may be used:
- to enrich rod outer segment (ROS) membranes
- as a spin probe in vesicles/bilayer to prepare samples for electron spin resonance (ESR) experiments
- as a component in liposomes to assess the mobility of lipid headgroups
Packaging
5 mL Amber Glass Screw Cap Vial (810610P-1mg)
Certificates of Analysis (COA)
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Biophysical journal, 61(6), 1443-1453 (1992-06-01)
A new general method for the determination of electrostatic potentials at biological surfaces is presented. The approach is based on measurement of the collision frequency of a charged nitroxide in solution with a nitroxide fixed to the surface at the
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