810602P
Avanti
16:0-7 Doxyl PC
Avanti Polar Lipids 810602P, powder
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Synonym(s):
1-palmitoyl-2-stearoyl-(7-doxyl)-sn-glycero-3-phosphocholine
Empirical Formula (Hill Notation):
C46H90N2O10P
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810602P-1mg)
manufacturer/tradename
Avanti Polar Lipids 810602P
lipid type
ESR probes
phospholipids
shipped in
dry ice
storage temp.
−20°C
General description
Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.
Phosphatidylcholine (PC), a strong bilayer-forming lipid is the most common phospholipid in mammalian membranes. Several prokaryotic and eukaryotic pathogens has phosphorylcholine as its structural constituent.
Biochem/physiol Actions
Phosphorylcholine (PC) possesses immunomodulatory properties.
Packaging
5 mL Clear Glass Sealed Ampule (810602P-1mg)
Preparation Note
Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM , Additional supplemental information.
Regulatory Information
新产品
Certificates of Analysis (COA)
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The Membranes of Cells (2016)
W Harnett et al.
Immunology today, 20(3), 125-129 (1999-04-22)
Phosphorylcholine (PC) is a structural component of a variety of prokaryotic and eukaryotic pathogens. In some cases, PC in infectious agents can benefit the infected host due to its targeting by both the innate and adaptive immune responses. However, as
Insight into antibody combining sites using nuclear magnetic resonance and spin label haptens
McConnell HM
Advances in Protein Chemistry, 49, 135-148 (1996)
ESR of spin-labeled bacteriophage M13 coat protein in mixed phospholipid bilayers
de Jongh HH
Biochimica et Biophysica Acta, 1024, 82-88 (1990)
Ultra-stable temperature control in EPR experiments: thermodynamics of gel-to-liquid phase transition in spin-labeled phospholipid bilayers and bilayer perturbations by spin labels
Alaouie AM, et. al.
Journal of Magnetic Resonance, 182, 229-238 (2006)
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