810384P
Avanti
TopFluor® TMR PI(4,5)P2
Avanti Polar Lipids 810384P, powder
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Synonym(s):
1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphoinositol-4.5-bisphosphate (ammonium salt)
Empirical Formula (Hill Notation):
C54H92BF2N6O21P3
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 50 μg (with stopper and crimp cap (810384P-50ug))
pkg of 2 × 50 μg (with stopper and crimp cap (810384P-100ug))
manufacturer/tradename
Avanti Polar Lipids 810384P
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidylinositol 4,5-bisphosphate/(PI(4,5)P2 or PIP2) is one of the major constituent of the inner leaflet of the plasma membrane, especially in eukaryotic cells. It is an important phosphoinositide phosphate species in mammalian cells.
Biochem/physiol Actions
Phosphatidylinositol 4,5-bisphosphate/(PI(4,5)P2 or PIP2) actively participates in numerous cellular signaling pathways. It acts as a precursor of phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P3). It helps in the assembly of several viruses, like human immunodeficiency virus 1 (HIV1).
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (810384P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (810384P-50ug)
Legal Information
TopFluor is a registered trademark of Avanti Polar Lipids, Inc.
Flash Point(F)
No data available
Flash Point(C)
No data available
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Multivalent cation-bridged PI (4, 5) P2 clusters form at very low concentrations
Wen Y, et al.
Biophysical Journal, 114(11), 2630-2639 (2018)
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