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810332C

Avanti

18:1 PE CF

Avanti Polar Lipids 810332C

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Synonym(s):
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) (ammonium salt)
Empirical Formula (Hill Notation):
C62H94N3O14P
CAS Number:
799268-49-8
Molecular Weight:
1136.40
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

solution

packaging

pkg of 1 × 1 mL (810332C-1mg)
pkg of 5 × 1 mL (810332C-5mg)
pkg of 5 × 2 mL (810332C-10mg)

manufacturer/tradename

Avanti Polar Lipids 810332C

concentration

1 mg/mL (810332C-10mg)
1 mg/mL (810332C-1mg)
1 mg/mL (810332C-5mg)

shipped in

dry ice

storage temp.

−20°C

General description

Phosphoethanolamine (PHOS) is a precursor to phosphatidylcholine and phosphatidylethanolamine. 18:1 PE CF is a green fluorescent tagged phosphatidylethanolamine.

Application

18:1 PE CF may be used:
  • to spike human serum
  • to prepare concentrated lipid mix, PC:PE:fluoPE to assess basal binding properties and PC:PE:fluoPE:PIP to assess specific binding properties of the protein to each phosphoinositides (PIP)
  • to prepare the large unilamellar vesicles (LUVs)
  • in the preparation of fluorescent phosphoinositide?containing liposomes
  • for fluorescent labeling of total lipids to the initial liposome formulation mixture
  • in the formulation of pegylated magneto-liposomes (MLs) and transferrin (Tf) embedding

Biochem/physiol Actions

Phosphatidylethanolamine controls the membrane fluidity in eukaryotic cells. Phosphoethanolamine (PHOS) has the ability to repress tumour growth both in vitro and in vivo. It possesses anticarcinogenic effects. It can also prevent the mRNA expression of cyclin D1 and VEGFR1 (vascular endothelial growth factor receptor 1).

Packaging

5 mL Amber Glass Screw Cap Vial (810332C-10mg)
5 mL Amber Glass Screw Cap Vial (810332C-1mg)
5 mL Amber Glass Screw Cap Vial (810332C-5mg)

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

Regulatory Information

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Liposome Flotation Assays for Phosphoinositide-protein Interaction
Tronchere H and Boal F
Journal of Cell Science, 390(1), 1-13 (2015)
Enhanced blood-brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulation
Ding H, et al.
Nanotechnology, 25(5), 055101-055101 (2014)
Protein-Lipid Interaction by Fluorescence (PLIF) to Characterize and Screen for Inhibitors of Protein-Phosphoinositide Interactions
Ceccato L, et al.
Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.], 89(1), 19-31 (2017)
NUTS and BOLTS: applications of fluorescence-detected sedimentation
Kroe RR and Laue TM
Analytical biochemistry, 390(1), 1-13 (2009)
Yashi Wang et al.
Journal of controlled release : official journal of the Controlled Release Society, 321, 71-83 (2020-02-09)
Oxidative-stress defense system stands for the vulnerability of tumor cells because of the stronger oxidative stress existing in tumor sites. TRPA-1 has been found to be overexpressed in various tumors, related to the tumor proliferation and metastasis, and promote reactive
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