810280P
Avanti
TopFluor® Lyso PA
Avanti Polar Lipids 810280P, powder
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Synonym(s):
1-{12-[4-(dipyrrometheneboron difluoride)butanoyl]amino}dodecanoyl-2-hydroxy-sn-glycero-3-phosphate (ammonium salt)
Empirical Formula (Hill Notation):
C32H54BF2N4O8P
Recommended Products
Assay
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
form
powder
packaging
pkg of 1 × 1 mg (810280P-1mg)
manufacturer/tradename
Avanti Polar Lipids 810280P
shipped in
dry ice
storage temp.
−20°C
General description
Lysophosphatidic acid (LPA) is a water-soluble, bioactive phospholipid. It is seen in mammalian cells and tissues, including blood. LPA is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells.
Application
TopFluor® Lyso PA may be used as the chromophore and as a component in the formation of the Langmuir-Blodgett (LB) film.
Biochem/physiol Actions
Lysophosphatidic acid (LPA) is very essential in signaling. It may alter proliferation, survival, cytoskeletal changes and calcium influx. It plays a key role in neointimal formation, endothelium dysfunction, monocyte attraction and adhesion.
Packaging
5 mL Amber Glass Screw Cap Vial (810280P-1mg)
Legal Information
TopFluor is a registered trademark of Avanti Polar Lipids, Inc.
Certificates of Analysis (COA)
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Diffusional motion as a gauge of fluidity and interfacial adhesion. Supported alkylphosphonate monolayers
Baumler SM, et al.
Journal of Colloid and Interface Science, 468, 145-155 (2016)
Lysophosphatidic acid triggers apoptosis in HeLa cells through the upregulation of tumor necrosis factor receptor superfamily member 21
Dong Y, et al.
Mediators of Inflammation (2017)
Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance
Lin ME, et al.
Prostaglandins & other lipid mediators, 91(3-4), 130-138 (2010)
Lysophosphatidic Acid Triggers Apoptosis in HeLa Cells through the Upregulation of Tumor Necrosis Factor Receptor Superfamily Member 21
Dong Y, et al.
Mediators of Inflammation (2017)
Lauren P Saunders et al.
The Journal of biological chemistry, 286(34), 30130-30141 (2011-07-02)
Autotaxin (ATX) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), initiating signaling cascades leading to cancer metastasis, wound healing, and angiogenesis. Knowledge of the pathway and kinetics of LPA synthesis by ATX is critical for
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