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810253P

Avanti

dehydroergosterol (DHE)

ergosta-5,7,9(11),22-tetraen-3β-ol, powder

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Synonym(s):
DHE
Empirical Formula (Hill Notation):
C28H42O
CAS Number:
516-85-8
Molecular Weight:
394.63
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (with stopper and crimp cap (810253P-1mg))

manufacturer/tradename

Avanti Polar Lipids 810253P

shipped in

dry ice

storage temp.

−70°C

InChI

1S/C28H42O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,14,18-20,22,24-25,29H,11-13,15-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,27-,28+/m0/s1

InChI key

QSVJYFLQYMVBDR-CMNOFMQQSA-N

General description

Dehydroergosterol (DHE) is a fluorescent sterol that possesses similar biophysical properties as cholesterol. It is found in yeast cells and other fungi.

Application

Dehydroergosterol (DHE) is suitable for the transfer of DHE from a population of donor (LD) to acceptor (LA) liposomes.

Biochem/physiol Actions

Dehydroergosterol (DHE) is used for the visualization of intracellular traffic and intracellular transport kinetics.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (810253P-1mg)

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mohsen Pourmousa et al.
The journal of physical chemistry. B, 118(26), 7345-7357 (2014-06-04)
Although dehydroergosterol (DHE) is one of the most commonly used cholesterol (CHOL) reporters, it has remained unclear why it performs well compared with most other CHOL analogues and what its possible limitations are. We present a comprehensive study of the
Molecular basis for sterol transport by StART-like lipid transfer domains
Horenkamp FA, et al.
The Embo Journal, 37(6) (2018)
Reynold Homan et al.
Analytical biochemistry, 441(1), 80-86 (2013-07-16)
We describe a simple but sensitive fluorescence method to accurately detect the esterification activity of lecithin:cholesterol acyltransferase (LCAT). The new assay protocol employs a convenient mix, incubate, and measure scheme. This is possible by using the fluorescent sterol dehydroergosterol (DHE)
Daniel Wüstner et al.
Microscopy research and technique, 74(1), 92-108 (2010-12-25)
Dehydroergosterol (DHE) is an intrinsically fluorescent sterol with absorption/emission in the ultraviolet (UV) region and biophysical properties similar to those of cholesterol. We compared the potential of UV-sensitive low-light-level wide-field (UV-WF) imaging with that of multiphoton (MP) excitation microscopy to
Olav Garvik et al.
Chemistry and physics of lipids, 159(2), 114-118 (2009-05-30)
The fluorescent sterol dehydroergosterol (DHE) is often used as a marker for cholesterol in cellular studies. We show by vesicle fluctuation analysis that DHE has a lower ability than cholesterol to stiffen lipid bilayers suggesting less efficient packing with phospholipid
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