810251P
Avanti
NBD-6 Cholesterol
Avanti Research™ - A Croda Brand 810251P, powder
Synonym(s):
5-cholesten-3β-ol 6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]caproate
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C39H58N4O5
CAS Number:
Molecular Weight:
662.90
UNSPSC Code:
12352211
NACRES:
NA.25
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810251P-1mg)
pkg of 1 × 5 mg (810251P-5MG)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810251P
shipped in
dry ice
storage temp.
−20°C
General description
NBD-6 Cholesterol is a fluorescent analog of the lipoprotein compound cholesterol, with NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) being the fluorescent group.
Application
NBD-6 Cholesterol has been used for NBD-cholesterol binding assay, to study the binding of fluorescent NBD cholesterol in the binding pocket concerning ASTER domains.
Biochem/physiol Actions
Cholesterol is produced from acetyl-CoA by a complex multistep mevalonate pathway. In mammals, liver is the main site of de novo cholesterol synthesis contributing to almost 80% of total cholesterol synthesis. Cholesterol and its metabolites, along with its precursors, play important roles in cellular membrane physiology. They also have roles in reproductive biology, dietary nutrient absorption, stress responses, salt and water balance and calcium metabolism.
Packaging
5 mL Amber Glass Screw Cap Vial (810299P-1MG)
5 mL Amber Glass Screw Cap Vial (810251P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
No data available
Flash Point(C)
No data available
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Molecular Nutrition And Food Research, 277-290 (2016)
Fluorescent and Luminescent Probes for Biological Activity (1999)
Cholesterol in health and disease.
Ira Tabas
The Journal of clinical investigation, 110(5), 583-590 (2002-09-05)
Pedro M R Cruz et al.
Frontiers in pharmacology, 4, 119-119 (2013-10-05)
While the unique metabolic activities of malignant tissues as potential targets for cancer therapeutics has been the subject of several recent reviews, the role of cholesterol metabolism in this context is yet to be fully explored. Cholesterol is an essential
Jaspreet Sandhu et al.
Cell, 175(2), 514-529 (2018-09-18)
The mechanisms underlying sterol transport in mammalian cells are poorly understood. In particular, how cholesterol internalized from HDL is made available to the cell for storage or modification is unknown. Here, we describe three ER-resident proteins (Aster-A, -B, -C) that
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