810241P
Avanti
TopFluor® TMR PE
Avanti Polar Lipids 810241P, powder
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Synonym(s):
1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3α,4α-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3- phosphoethanolamine
Empirical Formula (Hill Notation):
C50H76 BF2N4 O10P
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810241P-1mg)
manufacturer/tradename
Avanti Polar Lipids 810241P
shipped in
dry ice
storage temp.
−20°C
General description
Phosphoethanolamine contains a phosphate group linked with the second carbon of ethanolamine.
Biochem/physiol Actions
Phosphoethanolamine (PEA) is a precursor to phosphatidylethanolamine and phosphatidylcholine, involved in the biosynthesis of cell membrane. In human body, PEA is a product of degradation of sphingosine phosphate and endocannabinoid anandamide. PEA has potential cytotoxic properties and is known to induce the caspase-independent cell death. PEA is capable of inhibiting tumor growth in vitro and in vivo in mouse models.
Packaging
5 mL Amber Glass Screw Cap Vial (810241P-1mg)
Legal Information
TopFluor is a registered trademark of Avanti Polar Lipids, Inc.
Regulatory Information
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Certificates of Analysis (COA)
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Lisley I Mambelli et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 103, 18-28 (2018-04-11)
Phosphoethanolamine (PEA) is a fundamental precursor during the biosynthesis of cell membranes phospholipids. In the past few years, it has been described as a potential antitumor agent. In previous studies, we demonstrated that PEA showed antitumor properties in vitro and
Noam Pondé et al.
Ecancermedicalscience, 10, 681-681 (2016-12-03)
The use of unproven forms of therapy in cancer treatment is very common. In Brazil, the distribution by researchers to patients of an investigational agent called phophoethanolamine (PHOS) has led to a widely publicized scientific scandal. PHOS is a precursor
Dhaval Patel et al.
Oxidative medicine and cellular longevity, 2017, 4829180-4829180 (2017-08-09)
Phosphatidylethanolamine (PE) is the second most abundant phospholipid in mammalian cells. PE comprises about 15-25% of the total lipid in mammalian cells; it is enriched in the inner leaflet of membranes, and it is especially abundant in the inner mitochondrial
Ann C Kimble-Hill et al.
The journal of physical chemistry. B, 122(35), 8404-8415 (2018-06-08)
Phosphatidylinositol (PI) lipids are necessary for many cellular signaling pathways of membrane associated proteins, such as angiomotin (Amot). The Amot family regulates cellular polarity, growth, and migration. Given the low concentration of PI lipids in these membranes, it is likely
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