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810225C

Avanti

18:1 Dansyl PS

Avanti Research™ - A Croda Brand 810225C

Synonym(s):

1,2-dioleoyl-sn-glycero-3-phospho-L-serine-N-(5-dimethylamino-1-naphthalenesulfonyl) (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C54H95N4O12PS
CAS Number:
474943-03-8
Molecular Weight:
1055.39
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810225C-1mg)
pkg of 5 × 1 mL (810225C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810225C

concentration

1 mg/mL (810225C-1mg)
1 mg/mL (810225C-5mg)

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidylserine (PS), a glycerophospholipid, is found in the inner leaflet of the plasma membrane and in endocytic membranes. Dansyl ((dimethyl amino)naphthalene-1-sulfonYL) group produces blue or blue-green fluorescent adduct and thus can be used for various fluorescence based studies.

Application

18:1 Dansyl PS is suitable for preparation of liposomes for sedimentation assays and other fluorometric analysis like FRET.

Biochem/physiol Actions

Phosphatidylserine (PS) is an important cell cycle signaling molecule which contributes to the clearance of apoptotic cells. It is also known to trigger the blood coagulation process acting as a pro-coagulant surface.

Packaging

5 mL Amber Glass Screw Cap Vial (810225C-1mg)
5 mL Amber Glass Screw Cap Vial (810225C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Target Organs

Liver,Kidney, Respiratory system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

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Supplemental Data ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes
Advances in Planar Lipid Bilayers and Liposomes, 125(1), 99-111 (2011)
Laurent Meertens et al.
Cell host & microbe, 12(4), 544-557 (2012-10-23)
Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases. However, the molecular interactions mediating DV entry are poorly understood. We determined that TIM and TAM proteins, two receptor families that mediate the phosphatidylserine (PtdSer)-dependent phagocytic removal of
Barry R Lentz
Progress in lipid research, 42(5), 423-438 (2003-06-20)
This article addresses the role of platelet membrane phosphatidylserine (PS) in regulating the production of thrombin, the central regulatory molecule of blood coagulation. PS is normally located on the cytoplasmic face of the resting platelet membrane but appears on the
Peter A Leventis et al.
Annual review of biophysics, 39, 407-427 (2010-03-03)
Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in eukaryotic membranes. PS directs the binding of proteins that bear C2 or gamma-carboxyglutamic domains and contributes to the electrostatic association of polycationic ligands with cellular membranes. Rather than being evenly

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