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Merck
CN

810214C

Avanti

C6-NBD Phytosphingosine

Avanti Research™ - A Croda Brand

Synonym(s):

N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-phytosphingosine

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About This Item

Empirical Formula (Hill Notation):
C30H51N5O7
CAS Number:
477239-93-3
Molecular Weight:
593.76
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

C6-NBD Phytosphingosine, Avanti Research™ - A Croda Brand 810214C

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810214C-50ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810214C

concentration

0.05 mg/mL (810214C-50ug)

shipped in

dry ice

storage temp.

−20°C

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General description

C6-NBD Phytosphingosine is a fluorescent derivative of phytosphingosine (PHS). Its fluorescent property is due to presence of NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) group.

Application

C6-NBD Phytosphingosine or N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-phytosphingosine is suitable for use in membrane fusion and verification studies using forster resonance energy transfer (FRET).

Biochem/physiol Actions

Phytosphingosine (PHS) is a long-chain base sphingoid and a major constituent of various phytoceramides. PHS is abundantly present in skin, intestine, and kidneys of animals. It exhibits anti-inflammatory and antimicrobial properties. PHS is known to increase the expression of genes including transglutaminase 1 and involucrin, that are involved in keratinocyte differentiation in humans.

Packaging

5 mL Amber Glass Screw Cap Vial (810214C-50ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

易制毒化学品（2类）
危险化学品
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Fluorescent and Luminescent Probes for Biological Activity null
Endotoxin-adsorbing macrophage-mimetic hybrid liposome for sepsis treatment
Jiang LL, et al.
Chemical Engineering Journal, 371(1), 15-25 (2019)
Chunai Gong et al.
Journal of nanobiotechnology, 18(1), 92-92 (2020-06-18)
Cell membrane- covered drug-delivery nanoplatforms have been garnering attention because of their enhanced bio-interfacing capabilities that originate from source cells. In this top-down technique, nanoparticles (NPs) are covered by various membrane coatings, including membranes from specialized cells or hybrid membranes
Hyun Kyung Choi et al.
Archives of dermatological research, 309(10), 795-803 (2017-09-25)
Phytosphingosine (PHS) is a sphingoid that is a key component of phytoceramides NP, AP and EOP. PHS has been known to have anti-inflammation and antimicrobial activities and to stimulate epidermal differentiation. In addition, it is reported that PHS treatment notably

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