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Safety Information

810206X

Avanti

NBD Sphinganine

omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R)-2-aminooctadecane-1,3-diol, chloroform:methanol (9:1)

Synonym(s):

D-erythro-sphinganine-N-NBD; NBD-dihydrosphingosine

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About This Item

Empirical Formula (Hill Notation):
C24H41N5O5
CAS Number:
1246303-03-6
Molecular Weight:
479.61
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810206X-250ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810206X

concentration

0.25 mg/mL (810206X-250ug)

shipped in

dry ice

storage temp.

−20°C

General description

Sphinganine (dihydrosphingosine) is a common sphingoid base in phospholipids found in lesser amounts compared to sphingosine.

Application

NBD Sphinganine or omega (7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R)-2-aminooctadecane-1,3-diol is suitable for the determination of the dihydrosphingosine (DHS) localization to endoplasmic reticulum for the activation of activating transcription factor 6 (ATF6) protein.

Packaging

5 mL PTFE Screw Cap Vial with Foil Bag Argon overseal (810206X-250ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3

Target Organs

Eyes,Central nervous system, Liver,Kidney, Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Regulatory Information

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Arvin B Tam et al.
Developmental cell, 46(3), 327-343 (2018-08-08)
The unfolded protein response (UPR) is induced by proteotoxic stress of the endoplasmic reticulum (ER). Here we report that ATF6, a major mammalian UPR sensor, is also activated by specific sphingolipids, dihydrosphingosine (DHS) and dihydroceramide (DHC). Single mutations in a previously
Junliang Wan et al.
Journal of agricultural and food chemistry, 67(46), 12953-12961 (2019-10-23)
Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that

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