810189P
Avanti
TopFluor® PI(3,4,5)P3
Avanti Polar Lipids 810189P, powder
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Synonym(s):
1-oleoyl-2-{12-[4-(dipyrrometheneboron difluoride)butanoyl]amino}dodecanoyl-sn-glycero-3-phosphoinositol-3,4,5-trisphosphate (ammonium salt)
Empirical Formula (Hill Notation):
C56H108 BF2 N7O23P4
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 50 μg (with stopper and crimp cap (810189P-50ug))
manufacturer/tradename
Avanti Polar Lipids 810189P
shipped in
dry ice
storage temp.
−20°C
General description
PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) is restricted to the cell membrane of inner leaflet. TopFluor® PI(3,4,5)P3 is a fluorescently labeled-phosphoinositide derivative containing saturated acyl chain.
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an inadequate phospholipid present on the inner leaflet of the plasma membrane.
Biochem/physiol Actions
PI(3,4,5)P3 (diacylphosphatidylinositol-3,4,5-trisphosphate) serves as a substrate for PTEN (phosphatase and tensin homolog), a tumor suppressor protein. It has binding affinity towards the active site of phosphatase domain. TopFluor® PI(3,4,5)P3 might be useful in monitoring protein induced phosphoinositide clustering. This product is considered photostable than other fluorophores.
Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) plays a key role in inducing the cluster of Syntaxin1A at presynaptic terminals. It also regulates the activity protein kinase B/Akt.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (810189P-50ug)
Legal Information
TopFluor is a registered trademark of Avanti Polar Lipids, Inc.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Biophysical methods for the characterization of PTEN/lipid bilayer interactions
Harishchandra RK, et al.
Methods, 125-125 (2015)
Synaptic PI(3,4,5)P3 Is Required for Syntaxin1A Clustering and Neurotransmitter Release
Khuong TM, et al.
Neuron, 77(6), 1097-1108 (2013)
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
Ebner M, et al.
Molecular Cell, 65(3), 416-431 (2017)
Biophysical methods for the characterization of PTEN/lipid bilayer interactions
Harishchandra RK, et al.
Methods, 77, 125-135 (2015)
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