810185P
Avanti
TopFluor® PI(4)P
Avanti Polar Lipids 810185P, powder
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1-oleoyl-2-{6-[4-(dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-4-phosphate (ammonium salt)
C50H88BF2N5O17P2
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 50 μg (with stopper and crimp cap (810185P-50ug))
manufacturer/tradename
Avanti Polar Lipids 810185P
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidylinositol 4-phosphate (PI4P) is a precursor of phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2]. It is present in the membranes of Golgi apparatus.
Application
TopFluor® PI(4)P has been used as fluorescently labeled phosphoinositide to examine phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase (PTEN) interaction with anionic lipids.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (810185P-50ug)
Legal Information
TopFluor is a registered trademark of Avanti Polar Lipids, Inc.
WGK
WGK 3
Flash Point(F)
No data available
Flash Point(C)
No data available
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Langmuir : the ACS journal of surfaces and colloids, 32(7), 1732-1741 (2016-02-02)
Phosphatidylinositol phosphate (PIP) lipids are critical to many cell signaling pathways, in part by acting as molecular beacons that recruit peripheral membrane proteins to specific locations within the plasma membrane. Understanding the biophysics of PIP-protein interactions is critical to developing
Biophysical methods for the characterization of PTEN/lipid bilayer interactions
Methods, 77, 125-135 (2015)
PI4P and PI (4, 5) P2 are essential but independent lipid determinants of membrane identity
Science, 337(6095), 727-730 (2012)
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