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1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3α,4α-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine
C53H82 BF2N4 O10P
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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810180P-1mg)
manufacturer/tradename
Avanti Polar Lipids
shipped in
dry ice
storage temp.
−20°C
General description
Tetramethylrhodamine (TMR) phosphatidylcholine (PC) is a fatty acid labeled fluorescent phospholipid. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotes. It is the prime metabolite of glycerolipid metabolism.
Application
TopFluor® TMR PC or 1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3α,4α-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine may be used for the formation of lipid membranes in microarrays.
Biochem/physiol Actions
TopFluor®-labeled lipids have spectral properties similar to tetramethylrhodamine (TMR).
Packaging
5 mL Amber Glass Screw Cap Vial (810180P-1mg)
Legal Information
TopFluor is a registered trademark of Avanti Polar Lipids, Inc.
Certificates of Analysis (COA)
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Biochimica et biophysica acta. General subjects, 1864(2), 129330-129330 (2019-03-31)
Micro-chamber arrays enable highly sensitive and quantitative bioassays at the single-molecule level. Accordingly, they are widely used for ultra-sensitive biomedical applications, e.g., digital PCR and digital ELISA. However, the versatility of micro-chambers is generally limited to reactions in aqueous solutions
Proceedings of the National Academy of Sciences of the United States of America, 115(12), 3066-3071 (2018-03-07)
Transmembrane protein 16F (TMEM16F) is a Ca2+-dependent phospholipid scramblase that translocates phospholipids bidirectionally between the leaflets of the plasma membrane. Phospholipid scrambling of TMEM16F causes exposure of phosphatidylserine in activated platelets to induce blood clotting and in differentiated osteoblasts to
Single-molecule analysis of phospholipid scrambling by TMEM16F
Proceedings of the National Academy of Sciences of the USA, 115(12), 3066-3071 (2018)
Microsystem for the single molecule analysis of membrane transport proteins
Biochimica et biophysica acta. General subjects, 1864(2), 129330-129330 (2020)
A phosphatidylinositol 4, 5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing.
Nature Communications, 9(1), 4259-4259 (2018)
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