810180C
Avanti
TopFluor® TMR PC
Avanti Polar Lipids 810180C
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Synonym(s):
1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3α,4α-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine
Empirical Formula (Hill Notation):
C53H82 BF2N4 O10P
Recommended Products
Assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810180C-1mg)
manufacturer/tradename
Avanti Polar Lipids 810180C
concentration
1 mg/mL (810180C-1mg)
shipped in
dry ice
storage temp.
−20°C
General description
Tetramethylrhodamine (TMR) phosphatidylcholine (PC) is an acyl-chain-modified fluorescently labeled phospholipid. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotes and a prime metabolite of glycerolipid metabolism.
Application
TopFluor® TMR PC or 1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3α,4α-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine has been used to label biotinylated giant plasma membrane vesicles (GPMV). It is also suitable for the formation of lipid membranes in microarrays.
Biochem/physiol Actions
TopFluor®-labeled lipids have spectral properties similar to tetramethylrhodamine (TMR).
Packaging
5 mL Amber Glass Screw Cap Vial (810180C-1mg)
Legal Information
TopFluor is a registered trademark of Avanti Polar Lipids, Inc.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
Target Organs
Central nervous system, Liver,Kidney
WGK
WGK 3
Regulatory Information
易制毒化学品（2类）
危险化学品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Rikiya Watanabe et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(12), 3066-3071 (2018-03-07)
Transmembrane protein 16F (TMEM16F) is a Ca2+-dependent phospholipid scramblase that translocates phospholipids bidirectionally between the leaflets of the plasma membrane. Phospholipid scrambling of TMEM16F causes exposure of phosphatidylserine in activated platelets to induce blood clotting and in differentiated osteoblasts to
Single-molecule analysis of phospholipid scrambling by TMEM16F
Rikiya W, et al.
Proceedings of the National Academy of Sciences of the USA, 115(12), 3066-3071 (2018)
A phosphatidylinositol 4, 5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing.
Mu L, et al.
Nature Communications, 9(1), 4259-4259 (2018)
Libing Mu et al.
Nature communications, 9(1), 4259-4259 (2018-10-17)
Phagocytosis is one of the earliest cellular functions, developing approximately 2 billion years ago. Although FcR-based phagocytic signaling is well-studied, how it originated from ancient phagocytosis is unknown. Lipid redistribution upregulates a phagocytic program recapitulating FcR-based phagocytosis with complete dependence
César Botella et al.
Progress in lipid research, 65, 12-23 (2016-11-23)
In plant cells, phosphatidylcholine (PC) is a major glycerolipid of most membranes but practically lacking from the plastid internal membranes. In chloroplasts, PC is absent from the thylakoids and the inner envelope membrane. It is however the main component of
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