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810175C

Avanti

18:1-06:0 NBD PA

Avanti Research™ - A Croda Brand 810175C

Synonym(s):

1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphate (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C33H56N5O11P
CAS Number:
474942-97-7
Molecular Weight:
729.80
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810175C-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810175C

concentration

1 mg/mL (810175C-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidic acid (PA) is an amphipathic lipid containing a polar head group and two long hydrophobic acyl chains. PA is an anionic and a membrane structural lipid. 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) PA is a fluorescent analog NBD attached to the sn-2 fatty acid of PA.

Application

18:1-06:0 NBD PA or 1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphate (ammonium salt) is suitable to study the effects of NBD-PA induced vesiculation on epidermal growth factor receptor (EGFR) endocytosis in mammalian cells and the co-localization of fluorescently-labeled Poly(A)-Specific Ribonuclease (PARN) with the NBD-tagged PA that outlines the close proximity phospholipase D (PLD2) and PARN.

Biochem/physiol Actions

Phosphatidic acid (PA) is a secondary messenger involved in various cellular processes and a bioactive lipid. It acts as a parent compound for more complex membrane phospholipids.

Packaging

5 mL Amber Glass Screw Cap Vial (810175C-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

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Bioactive Lipids
An Introduction to Biological Membranes, , number=(, pages=), 453-478 (2016)
Lipid second messengers and Receptors
Encyclopedia of Endocrine Diseases, 77(3), 329-334 (2004)
Taylor E Miller et al.
Biology open, 6(2), 176-186 (2016-12-25)
The removal of mRNA transcript poly(A) tails by 3'→5' exonucleases is the rate-limiting step in mRNA decay in eukaryotes. Known cellular deadenylases are the CCR4-NOT and PAN complexes, and poly(A)-specific ribonuclease (PARN). The physiological roles and regulation for PARN is
Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties
Putta P, et al.
Biochimica et Biophysica Acta, 1858(11), 2709-2716 (2016)
Priya Putta et al.
Biochimica et biophysica acta, 1858(11), 2709-2716 (2016-08-03)
Phosphatidic acid (PA) is a crucial membrane phospholipid involved in de novo lipid synthesis and numerous intracellular signaling cascades. The signaling function of PA is mediated by peripheral membrane proteins that specifically recognize PA. While numerous PA-binding proteins are known
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