810151P
Avanti
14:0-06:0 NBD PE
Avanti Polar Lipids 810151P, powder
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Synonym(s):
1-myristoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoethanolamine
Empirical Formula (Hill Notation):
C31H52N5O11P
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810151P-1mg)
manufacturer/tradename
Avanti Polar Lipids 810151P
shipped in
dry ice
storage temp.
−20°C
General description
N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) phosphoethanolamine (NBD PE) is a fluorescently labeled lipid localized at the membrane interface. The molecule contains fluorescent NBD label attached to the headgroup of phosphatidylethanolamine. Phosphoethanolamine is the second most abundant, metabolically related aminophospholipid, mostly enriched in brain.
Biochem/physiol Actions
Phosphoethanolamine of cardiac myocytes minimizes the cell damage after ischemia. N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) phosphoethanolamine (NBD PE) aids is monitoring the Red edge excitation shift (REES) effects with the unique motional and dielectric properties it possesses.
Packaging
5 mL Amber Glass Screw Cap Vial (810151P-1mg)
Certificates of Analysis (COA)
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Application of NBD-labeled lipids in membrane and cell biology
Fluorescent methods to study biological membranes, 37-50 (2012)
S C Lopes et al.
Biochimica et biophysica acta. Biomembranes, 1861(6), 1152-1161 (2019-03-07)
Mitochondrial membranes are pointed out as the site of cardiotoxic action of local anaesthetics. Its three main phospholipids components are phosphatidylcholine, phosphatidylethanolamine and cardiolipin. Cardiolipins, in eukaryotes, are only found in mitochondria and are essential for the maintenance of its
Jean E Vance et al.
Biochimica et biophysica acta, 1831(3), 543-554 (2012-09-11)
Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are metabolically related membrane aminophospholipids. In mammalian cells, PS is required for targeting and function of several intracellular signaling proteins. Moreover, PS is asymmetrically distributed in the plasma membrane. Although PS is highly enriched in
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