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810133C

Avanti

18:1-12:0 NBD PC

Avanti Research™ - A Croda Brand 810133C

Synonym(s):

1-Oleoyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-Glycero-3-Phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C44H76N5O11P
CAS Number:
190792-36-0
Molecular Weight:
882.07
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810133C-1mg)
pkg of 5 × 1 mL (810133C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810133C

concentration

1 mg/mL (810133C-1mg)
1 mg/mL (810133C-5mg)

lipid type

fluorescent lipids
phospholipids

shipped in

dry ice

storage temp.

−20°C

General description

Phosphatidylcholine (PC) is a prime metabolite in eukaryotes glycerolipid metabolism, mainly synthesized in liver. It is a major element of lipoproteins, bile and lung surfactant. NBD PC contains 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) covalently attached to phosphatidylcholine.

Application

18:1-06:0 NBD PC is suitable for:
  • the generation giant unilamellar vesicles (GUVs) subjected to fluorescence microscopy
  • labelling lipid bilayers formed by vesicle fusion in order to study the lipid distribution by fluorescence microscopy
  • the preparation of phospholipid-coated beads

Biochem/physiol Actions

7-nitrobenz-2-oxa-1,3-diazol-4-yl phosphatidylcholine (NBD PC) functions as a fluorescent analog in biological membranes in order to study the cellular processes.

Packaging

5 mL Amber Glass Screw Cap Vial (810133C-1mg)
5 mL Amber Glass Screw Cap Vial (810133C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

Regulatory Information

易制毒化学品（2类）
危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Laura K Cole et al.
Biochimica et biophysica acta, 1821(5), 754-761 (2011-10-08)
Phosphatidylcholine (PC) is the major phospholipid component of all plasma lipoprotein classes. PC is the only phospholipid which is currently known to be required for lipoprotein assembly and secretion. Impaired hepatic PC biosynthesis significantly reduces the levels of circulating very
Haijia Yu et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(16), 4362-4367 (2016-04-05)
Organelles are in constant communication with each other through exchange of proteins (mediated by trafficking vesicles) and lipids [mediated by both trafficking vesicles and lipid transfer proteins (LTPs)]. It has long been known that vesicle trafficking can be tightly regulated
Wan-Chen Lin et al.
Biophysical journal, 90(1), 228-237 (2005-10-11)
A fundamental attribute of cell membranes is transmembrane asymmetry, specifically the formation of ordered phase domains in one leaflet that are compositionally different from the opposing leaflet of the bilayer. Using model membrane systems, many previous studies have demonstrated the
Henry A Boumann et al.
Biochimica et biophysica acta, 1788(7), 1444-1451 (2009-04-21)
Anammox bacteria that are capable of anaerobically oxidizing ammonium (anammox) with nitrite to nitrogen gas produce unique membrane phospholipids that comprise hydrocarbon chains with three or five linearly condensed cyclobutane rings. To gain insight into the biophysical properties of these
Sang-Yeob Kim et al.
PloS one, 12(4), e0174603-e0174603 (2017-04-05)
The removal of unwanted or damaged cells by phagocytes is achieved via a finely regulated cleaning process called efferocytosis. To characterize the mechanisms through which phagocytes control the intake of apoptotic cells, we investigated how the phagocyte's appetite for engulfed
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