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Merck
CN

810128C

Avanti

12:0 Lyso NBD PC

Avanti Research™ - A Croda Brand

Synonym(s):

1-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-2-hydroxy-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C26H44N5O10P
CAS Number:
1246303-00-3
Molecular Weight:
617.63
UNSPSC Code:
12352211
NACRES:
NA.25

Key Documents

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Product Name

12:0 Lyso NBD PC, Avanti Research™ - A Croda Brand 810128C

assay

>99% (LPC; may contain up to 10% of the 2-LPC isomer, TLC)

form

liquid

packaging

pkg of 1 × 1 mL (810128C-1mg), pkg of 5 × 1 mL (810128C-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810128C

concentration

1 mg/mL (810128C-1mg), 1 mg/mL (810128C-5mg)

lipid type

fluorescent lipids

shipped in

dry ice

storage temp.

−20°C

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Application

12:0 Lyso NBD PC may be used as a substrate to measure the enzymatic activity of recombinant human lysophosphatidylcholine acyltransferase 3 (rhLPCAT3) and to study the function of lysophosphatidic acid (LPA) as an inhibitor in the autotaxin (ATX) catalysis.

Packaging

5 mL Clear Glass Sealed Ampule (810128C-1mg)
5 mL Clear Glass Sealed Ampule (810128C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

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Fernando Salgado-Polo et al.
The Journal of biological chemistry, 293(37), 14312-14327 (2018-07-22)
Autotaxin (ATX) is a secreted glycoprotein and the only member of the ectonucleotide pyrophosphatase/phosphodiesterase family that converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). LPA controls key responses, such as cell migration, proliferation, and survival, implicating ATX-LPA signaling in various (patho)physiological
Lauren P Saunders et al.
The Journal of biological chemistry, 286(34), 30130-30141 (2011-07-02)
Autotaxin (ATX) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), initiating signaling cascades leading to cancer metastasis, wound healing, and angiogenesis. Knowledge of the pathway and kinetics of LPA synthesis by ATX is critical for
Stephen M Baumler et al.
Langmuir : the ACS journal of surfaces and colloids, 33(12), 2986-2992 (2017-03-08)
The translational diffusion dynamics of the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) at a planar phosphorylated support surface containing metal ions (Mg2+, Ca2+, Ba2+, Ni2+, Zn2+, Cd2+, Zr4+) was investigated using X-ray photoelectron spectroscopy (XPS) and fluorescence recovery after photobleaching (FRAP). Fluorescence

Articles

Critical Micelle Concentrations (CMCs) - Avanti Research™ Polar Lipids

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

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