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810110P

Avanti

12-NBD Stearate

Avanti Research™ - A Croda Brand 810110P, powder

Synonym(s):

12-N-methyl-(7-nitrobenz-2-oxa-1,3-diazo)aminostearic acid

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About This Item

Empirical Formula (Hill Notation):
C25H40N4O5
CAS Number:
117056-67-4
Molecular Weight:
476.61
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (810110P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810110P

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C25H40N4O5/c1-3-4-5-12-15-20(16-13-10-8-6-7-9-11-14-17-23(30)31)28(2)21-18-19-22(29(32)33)25-24(21)26-34-27-25/h18-20H,3-17H2,1-2H3,(H,30,31)

InChI key

SAAVELCIPHKGJE-UHFFFAOYSA-N

General description

12-NBD Stearate is amphipathic, nonesterifiable fluorescent fatty acid probe and is a long-chain fatty acid (LCFA) derivative.

Application

12-NBD Stearate has been used in the fluorescent labeling of omega-3 fatty acid in biomaterial films and as a ligand for fatty acid binding protein 5 (FABP5) in competitive binding based high throughput fluorescence displacement assay. It may be used a ligand fluorescence displacement assay of fatty-acid binding protein 5 (FABP5).

Biochem/physiol Actions

12-NBD Stearate incorporated in lipid droplets and is used majorly in fluorescence displacement binding studies of fatty-acid binding proteins. The sterol carrier protein-2 (SCP-2) 15-kDa isoform favours NBD Stearate transport. The uptake of NBD Stearate is regulated by fatty acid binding protein (FABP) expression regulates uptake and inhibited by filipin III.

Packaging

5 mL Amber Glass Screw Cap Vial (810110P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tracking of drug release and material fate for naturally derived omega-3 fatty acid biomaterials
Faucher KM, et al.
Annals of Biomedical Engineering, 44(3), 782-792 (2016)
Lu Bai et al.
ACS infectious diseases, 6(4), 637-648 (2020-02-14)
Assembly of the bacterial cell wall requires not only the biosynthesis of cell wall components but also the transport of these metabolites to the cell exterior for assembly into polymers and membranes required for bacterial viability and virulence. LprG is
Targeting fatty acid binding protein (FABP) anandamide transporters-a novel strategy for development of anti-inflammatory and anti-nociceptive drugs
Berger WT, et al.
PLoS ONE, 7(12) (2012)
Targeting fatty acid binding protein (FABP) anandamide transporters-a novel strategy for development of anti-inflammatory and anti-nociceptive drugs
Berger WT, et al.
Testing, 7(12) (2012)
B P Atshaves et al.
The Journal of biological chemistry, 276(27), 25324-25335 (2001-05-03)
Despite the critical role lipid droplets play in maintaining energy reserves and lipid stores for the cell, little is known about the regulation of the lipid or protein components within the lipid droplet. Although immunofluorescence of intact cells as well
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