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About This Item
Empirical Formula (Hill Notation):
C25H40N4O5
CAS Number:
Molecular Weight:
476.61
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
Product Name
12-NBD Stearate, Avanti Research™ - A Croda Brand, powder
SMILES string
[N+](=O)([O-])c1c2n[o]nc2c(cc1)N(C(CCCCCCCCCCC(=O)O)CCCCCC)C
InChI
1S/C25H40N4O5/c1-3-4-5-12-15-20(16-13-10-8-6-7-9-11-14-17-23(30)31)28(2)21-18-19-22(29(32)33)25-24(21)26-34-27-25/h18-20H,3-17H2,1-2H3,(H,30,31)
InChI key
SAAVELCIPHKGJE-UHFFFAOYSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810110P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
fluorescent lipids
shipped in
dry ice
storage temp.
−20°C
Application
12-NBD Stearate has been used in the fluorescent labeling of omega-3 fatty acid in biomaterial films and as a ligand for fatty acid binding protein 5 (FABP5) in competitive binding based high throughput fluorescence displacement assay. It may be used a ligand fluorescence displacement assay of fatty-acid binding protein 5 (FABP5).
Biochem/physiol Actions
12-NBD Stearate incorporated in lipid droplets and is used majorly in fluorescence displacement binding studies of fatty-acid binding proteins. The sterol carrier protein-2 (SCP-2) 15-kDa isoform favours NBD Stearate transport. The uptake of NBD Stearate is regulated by fatty acid binding protein (FABP) expression regulates uptake and inhibited by filipin III.
General description
12-NBD Stearate is amphipathic, nonesterifiable fluorescent fatty acid probe and is a long-chain fatty acid (LCFA) derivative.
Packaging
5 mL Amber Glass Screw Cap Vial (810110P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
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Targeting fatty acid binding protein (FABP) anandamide transporters-a novel strategy for development of anti-inflammatory and anti-nociceptive drugs
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B P Atshaves et al.
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