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Merck
CN

800742C

Avanti

N-20:4 L-Serine (ARA-S)

Avanti Research - A Croda Brand

Synonym(s):

ARA-S; 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine; (S)-3-hydroxy-2-(5Z,8Z,11Z,14Z)-eicosatetraenamidopropanoate; (S)-3-hydroxy-2-arachidonamidopropanoate

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About This Item

Empirical Formula (Hill Notation):
C23H37NO4
CAS Number:
Molecular Weight:
391.54
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
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Product Name

N-20:4 L-Serine (ARA-S), N-arachidonoyl L-serine, chloroform

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 1 mL (800742C-5mg)

manufacturer/tradename

Avanti Research - A Croda Brand 800742C

concentration

5 mg/mL (800742C-5mg)

lipid type

bioactive lipids
phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

General description

N-20:4 L-Serine (ARA-S), a unique lipoamino acid is endogenous in nature. It is localized to the brain. It has structural resemblance with anandamide, an endocannabinoid.

Biochem/physiol Actions

N-20:4 L-Serine (ARA-S) is a signaling lipid that regulates neuronal-type Ca2+ channels in the brain. ARA-S is known to produce endothelium-dependent arterial vasodilatation in vitro. It is also found to exert neuroprotective action following brain injury.

Packaging

5 mL Clear Glass Sealed Ampule (800742C-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC


pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system

wgk

WGK 3

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

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Esther Shohami et al.
British journal of pharmacology, 163(7), 1402-1410 (2011-03-23)
Traumatic brain injury (TBI) represents the leading cause of death in young individuals. It triggers the accumulation of harmful mediators, leading to secondary damage, yet protective mechanisms are also set in motion. The endocannabinoid (eCB) system consists of ligands, such
Robert C Murphy et al.
Journal of lipid research, 60(2), 219-226 (2019-01-05)
Leukotrienes (LTs) are autacoids derived from the precursor arachidonic acid (AA) via the action of five-lipoxygenase (5-LO). When inflammatory cells are activated, 5-LO translocates to the nuclear membrane to initiate oxygenation of AA released by cytosolic phospholipase A2 (cPLA2) into
Ziqiang Guan
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(26), 2814-2821 (2009-03-24)
Discovery and structural elucidation of novel brain lipids hold great promise in revealing new lipid functions in the brain and in understanding the biochemical mechanisms underlying brain physiology and pathology. The revived interests in searching for novel brain lipids have



Global Trade Item Number

SKUGTIN
800742C-5MG04061835351114