All Photos(1)
Synonym(s):
N-oleoyl(d9)-D-erythro-sphingosylphosphorylcholine
Empirical Formula (Hill Notation):
C41H72 D9N2O6P
Recommended Products
Assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (791649C-1mg)
manufacturer/tradename
Avanti Polar Lipids
concentration
1 mg/mL (791649C-1mg)
shipped in
dry ice
storage temp.
−20°C
General description
18:1-d9 SM (N-oleoyl(d9)-D-erythro-sphingosylphosphorylcholine) is a deuterated derivative of 18:1-SM (N-oleoyl-D-erythro-sphingosylphosphorylcholine). 18:1- SM is a sphingomyelin which is present in aqueous humor. 18:1-SM or oleoyl-sphingomyelin, comprises quaternary ammonium group. 18:1-SM or oleoyl-sphingomyelin due to its miscible property is incapable of sequestering with cholesterol-rich domains.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH® LIPIDOMIX® Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample.
Application
18:1-d9 SM (N-oleoyl(d9)-D-erythro-sphingosylphosphorylcholine) has been used as an extraction buffer component for lipid isolation from raft and non-raft fractions of synaptic vesicles (SV) from rat brain. It may be used as an internal standard to spike serum lipid extracts for liquid chromatography-mass spectrometry (LC/MS) analysis and ultra-high-performance supercritical fluid chromatography with quadrupole-time-of-flight mass spectrometry (UHPSFC/QTOF-MS) for signal normalization and quantification of pulmonary artery lipids form porcine.
Packaging
5 mL Clear Glass Sealed Ampule (791649C-1mg)
Legal Information
LIPIDOMIX is a registered trademark of Avanti Polar Lipids, Inc.
SPLASH is a registered trademark of Avanti Polar Lipids, Inc.
also commonly purchased with this product
Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
Target Organs
Central nervous system, Liver,Kidney
WGK
WGK 3
Regulatory Information
易制毒化学品（2类）
危险化学品
Certificates of Analysis (COA)
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Ayman J Aljohani et al.
Molecular vision, 19, 1966-1984 (2013-09-27)
To determine the differential profiles of sphingomyelin, sphingoid base, sphingoid base-1-phosphate and ceramide lipid species and their quantitative differences between control and glaucomatous aqueous humor (AQH) derived from human donors. AQH from control and primary open-angle glaucoma donors was collected
Alicia Gil-Ramirez et al.
Journal of chromatography. A, 1592, 173-182 (2019-02-03)
Pulmonary artery grafts are needed as cardiovascular bioprosthetics. For successful tissue recellularization after transplantation, lipids have to be removed from the donor artery. Developing a selective process to remove lipids without damaging the extracellular matrix greatly depends on knowing the
Richard M Epand et al.
Chemistry and physics of lipids, 132(1), 37-46 (2004-11-09)
Sphingomyelin from biological membranes forms segregated domains with cholesterol in fluid bilayers. However, a synthetic form of sphingomyelin with an oleoyl chain linked to sphingosine is not incorporated into cholesterol-rich domains. We have studied the properties of mixtures of oleoyl-sphingomyelin
John Williams et al.
Bioanalysis, 12(3), 143-158 (2020-02-14)
Aim: Very long chain fatty acids (VLCFAs) have been identified as biomarkers for several peroxisomal disorders necessitating the need for reliable biomarker assays in particular C20, C22, C24, C26 in cerebrospinal fluid (CSF). Until now no absolute quantitation assay for
Michael S Gardner et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1118-1119, 137-147 (2019-04-30)
Progress toward better diagnosis and treatment of lipid metabolism-related diseases requires high throughput approaches for multiplexed quantitative analysis of structurally diverse lipids, including phospholipids (PLs). This work demonstrates a simplified "one-pot" phospholipid extraction protocol, as an alternative to conventional liquid-liquid
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