All Photos(1)
Synonym(s):
1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoethanolamine
Empirical Formula (Hill Notation):
C38H67D7NO8P
Recommended Products
Assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (791638C-1mg)
manufacturer/tradename
Avanti Polar Lipids
concentration
1 mg/mL (791638C-1mg)
shipped in
dry ice
storage temp.
−20°C
General description
15:0-18:1-d7-PE (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoethanolamine) is a deuterated phospholipid. The lipid comprises phosphatidylethanolamine attached to pentadecanoic acid and oleic acid. Oleic acid harbors the deuterium ions. Phosphatidylethanolamine is a membrane phospholipid and serves as an intermediate in other glycerophospholipid synthesis.
This deuterium labeled lipid is also available in a formulation of multiple lipid standards. The SPLASH® LIPIDOMIX® Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample.
Application
15:0-18:1-d7-PE (1-pentadecanoyl-2-oleoyl(d7)-sn-glycero-3-phosphoethanolamine) has been used:
- as a component of extraction solvent for lipid isolation from biological samples,
- as an internal standard for spiking serum samples for liquid chromatography with tandem mass spectrometry (LC-MS/MS)
- as an internal standard to spike plasma samples for fourier transform mass spectrometry (FTMS) analysis
Biochem/physiol Actions
Phosphatidylethanolamine (PE) regulates protein folding, protein modification, autophagy and cell division. PE serves as a substrate for glycosylphosphatidylinositol anchored proteins (GPI-APs) synthesis. Low levels of PE may be observed in Parkinson′s disease and may also inhibit protein maturation.
Packaging
2 mL Amber Glass Sealed Ampule (791638C-1mg)
Legal Information
LIPIDOMIX is a registered trademark of Avanti Polar Lipids, Inc.
SPLASH is a registered trademark of Avanti Polar Lipids, Inc.
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Description
Pricing
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Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
Target Organs
Central nervous system, Liver,Kidney
WGK
WGK 3
Flash Point(F)
does not flash
Flash Point(C)
does not flash
Regulatory Information
危险化学品
易制毒化学品（2类）
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Total Fatty Acid Analysis of Human Blood Samples in One Minute by High-Resolution Mass Spectrometry.
Sandra F Gallego et al.
Biomolecules, 9(1) (2018-12-29)
Total fatty acid analysis is a routine method in many areas, including lipotyping of individuals in personalized medicine, analysis of foodstuffs, and optimization of oil production in biotechnology. This analysis is commonly done by converting fatty acyl (FA) chains of
Michael S Gardner et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1118-1119, 137-147 (2019-04-30)
Progress toward better diagnosis and treatment of lipid metabolism-related diseases requires high throughput approaches for multiplexed quantitative analysis of structurally diverse lipids, including phospholipids (PLs). This work demonstrates a simplified "one-pot" phospholipid extraction protocol, as an alternative to conventional liquid-liquid
Bjoern Titz et al.
Computational and structural biotechnology journal, 18, 1056-1073 (2020-05-19)
Cigarette smoke (CS) causes adverse health effects and, for smoker who do not quit, modified risk tobacco products (MRTPs) can be an alternative to reduce the risk of developing smoking-related diseases. Standard toxicological endpoints can lack sensitivity, with systems toxicology
Chuchu Wang et al.
Nature communications, 11(1), 1531-1531 (2020-03-27)
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using
Dhaval Patel et al.
Oxidative medicine and cellular longevity, 2017, 4829180-4829180 (2017-08-09)
Phosphatidylethanolamine (PE) is the second most abundant phospholipid in mammalian cells. PE comprises about 15-25% of the total lipid in mammalian cells; it is enriched in the inner leaflet of membranes, and it is especially abundant in the inner mitochondrial
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