791300P
Avanti
18:0 PE-DTPA
Avanti Polar Lipids 791300P, powder
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Synonym(s):
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (ammonium salt)
Empirical Formula (Hill Notation):
C55H118N9O17P
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (791300P-5mg)
manufacturer/tradename
Avanti Polar Lipids 791300P
shipped in
dry ice
storage temp.
−20°C
General description
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (18:0 PE-DTPA) comprises synthetic phospholipid derivative of ethanolamine.
This chelate is used for preparing MRI contrast agents.
Application
18:0 PE-DTPA (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (ammonium salt)) has been used to chelate liposome-based cationic adjuvant formulation (CAF01). It has also been used in the liposome preparation for imaging studies
Biochem/physiol Actions
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (18:0 PE-DTPA) or PE-DTPA binding and interaction with the Toll-like receptor-2 regulates immune response . PE-DTPA acts as a lipopolysaccharide antagonist and elicits rescue functionality in sepsis by blocking nuclear factor κ -light-chain-enhancer of activated B cells based transcription.
Packaging
5 mL Amber Glass Screw Cap Vial (791300P-5mg)
Certificates of Analysis (COA)
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Brian Mog et al.
Nanotheranostics, 3(4), 342-355 (2019-11-15)
Specific targeting of inflammation remains a challenge in many pathologies, because of the necessary balance between host tolerance and efficacious inflammation resolution. Here, we discovered a short, 4-mer peptide which possesses antagonist properties towards CC chemokine receptor 2 (CCR2), but
Chunghyun Lee et al.
Molecules and cells, 27(2), 251-255 (2009-03-12)
Sepsis is the leading cause of death in critically ill patients. Today, around 60% of all cases of sepsis are caused by Gram-negative bacteria. The cell wall component lipopoly-saccharide (LPS) is the main initiator of the cascade of cellular reactions
Aneesh Thakur et al.
Frontiers in immunology, 9, 2825-2825 (2018-12-18)
Pulmonary tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains a global pandemic, despite the widespread use of the parenteral live attenuated Bacillus Calmette-Guérin (BCG) vaccine during the past decades. Mucosal administration of next generation TB vaccines has great
Jin Young Kang et al.
Immunity, 31(6), 873-884 (2009-11-26)
Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA
Zahraa S Al-Ahmady et al.
ACS nano, 13(11), 12470-12486 (2019-11-07)
The development of effective therapies for stroke continues to face repeated translational failures. Brain endothelial cells form paracellular and transcellular barriers to many blood-borne therapies, and the development of efficient delivery strategies is highly warranted. Here, in a mouse model
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