791268P
Avanti
DTPA-BSA (Gd)
DTPA-bis(stearylamide) (gadolinium salt), powder
Synonym(s):
(diethylenetriaminepentaacetic acid)-bis(stearylamide) (gadolinium salt); Gd-DTPA-BSA
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About This Item
Empirical Formula (Hill Notation):
C50H94GdN5O8
CAS Number:
Molecular Weight:
1050.56
UNSPSC Code:
12352211
NACRES:
NA.25
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 100 mg (791268P-100mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 791268P
shipped in
dry ice
storage temp.
−20°C
General description
DTPA-BSA (Gd) (diethylenetriaminepentaacetic acid)-bis(stearylamide) (gadolinium salt)) is an amphiphilic molecule with paramagnetic property.
Application
DTPA-BSA (Gd) (diethylenetriaminepentaacetic acid)-bis(stearylamide) (gadolinium salt)) has been used:
- in the preparation of nontargeting (NT) gadolinium peptide amphiphile micelles (PAMs) for the magnetic resonance imaging (MRI) of atherosclerotic lesions
- as a MRI agent in the preparation of lipid-like nanoparticles (LLNs) for small interfering RNA (siRNA) encapsulation
- as a MRI agent in the preparation of paramagnetic saposin C and dioleylphosphatidylserine (SapC-DOPS) vesicles for imaging glioblastoma multiforme (GBM) tumors
Biochem/physiol Actions
Gd-DTPA-BSA is useful as magnetic resonance imaging (MRI) agent and the gadolinium ion enables the generation of bright images by lowering the longitudinal relaxation time.
Packaging
5 mL Amber Glass Screw Cap Vial (791268P-100mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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F Jasanada et al.
Bioconjugate chemistry, 7(1), 72-81 (1996-01-01)
In order to use the LDL receptor pathway to target radionuclides to cancer sites for imaging and diagnostic purposes, a labeling procedure of LDL with 111In using the DTPA-bis(stearylamide) (L) has been developed. This bifunctional ligand is intended to be
Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents
Luo X, et al.
Nanoscale, 9(4), 1575-1579 (2017)
Sang Pil Yoo et al.
ACS omega, 1(5), 996-1003 (2016-12-06)
The leading causes of morbidity and mortality globally are cardiovascular diseases, and nanomedicine can provide many improvements including disease-specific targeting, early detection, and local delivery of diagnostic agents. To this end, we designed fibrin-binding, peptide amphiphile micelles (PAMs), achieved by
Geralda A F van Tilborg et al.
Bioconjugate chemistry, 17(3), 741-749 (2006-05-18)
Apoptosis, or programmed cell death, plays an important role in the etiology of a variety of diseases, including cancer and myocardial infarction. Visualization of apoptosis would allow both early detection of therapy efficiency and evaluation of disease progression. To that
Imaging of brain tumors with paramagnetic vesicles targeted to phosphatidylserine
Winter PM, et al.
Journal of Magnetic Resonance Imaging : JMRI, 41(4), 1079-1087 (2015)
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