790304P
Avanti
Coag Reagent I
Avanti Polar Lipids 790304P, powder
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Synonym(s):
Coag Reagent, Coagulation Reagent I, contains DOPE:DOPS:DOPC (5:3:2 w/w)
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
form
powder
packaging
pkg of 2 × 100 mg (790304P-200mg)
pkg of 1 × 25 mg (790304P-25mg)
manufacturer/tradename
Avanti Polar Lipids 790304P
application(s)
microbiology
lipid type
phospholipids
shipped in
dry ice
storage temp.
−20°C
General description
Coag Reagent I comprises 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE), 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) in the ratio 5:3:2 w/w. They are present predominantly in the synaptic vesicle membrane. DOPC has choline group and DOPE comprises ethanolamine moiety. At neutral pH, DOPE and DOPC exist as a zwitterion whereas DOPS takes up a negative charge and has a serine group.
Application
Coag Reagent I has been used in the preparation of small unilamellar vesicles (SUVs) for α-synuclein binding studies. It may be used in the preparation of bilayers for reconstituting ryanodine receptor type 2 (RyR2) for single-channel recording studies. It may be used for glass supported lipid bilayers preparation.
Biochem/physiol Actions
Coag Reagent I mixed lipid is useful in the preparation of supported lipid bilayers and platelet membranes for coagulation studies. It is used in the small unilamellar vesicles (SUVs) generation for α-synuclein and squalamine binding studies.
Packaging
5 mL Clear Glass Sealed Ampule (790304P-200mg)
5 mL Clear Glass Sealed Ampule (790304P-25mg)
WGK
WGK 3
Flash Point(F)
No data available
Flash Point(C)
No data available
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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A natural product inhibits the initiation of alpha-synuclein aggregation and suppresses its toxicity
Perni M, et al.
Proceedings of the National Academy of Sciences of the USA, 114(6), E1009-E1017 (2017)
EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2
Klipp RC, et al.
Heart Rhythm : the Official Journal of the Heart Rhythm Society, 15(4), 578-586 (2018)
Nuclear magnetic resonance observation of ?-synuclein membrane interaction by monitoring the acetylation reactivity of its lysine side chains
Lee JH, et al.
Biochemistry, 55(35), 4949-4959 (2016)
A M van den Besselaar et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 4(6), 895-903 (1993-12-01)
The activated partial thromboplastin time (aPTT) is the most popular test for monitoring of heparin therapy. The purpose of the present study was to show that an aPTT reagent with good response to heparin can be prepared from synthetic phosphoglycerides.
Three-Dimensional Heterogeneous Structure Formation on a Supported Lipid Bilayer Disclosed by Single-Particle Tracking
Zhong Y & Wang G
Langmuir, 34(39), 11857-11865 (2018)
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