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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (700121P-5mg)
manufacturer/tradename
Avanti Polar Lipids 700121P
shipped in
dry ice
storage temp.
−20°C
InChI
1S/C29H52O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h19-27,30H,7-18H2,1-6H3/t20-,21-,22+,23+,24+,25-,26+,27+,28+,29-/m1/s1
InChI key
LGJMUZUPVCAVPU-HRJGVYIJSA-N
General description
It is predominantly present in pine oil.
Sitostanol is a 5α-saturated sitosterol derivative.
Sitostanol is a plant stanol and a hydrogenated form of sitosterol.
Application
Sitostanol is suitable for its use as a component in micelle preparation, used for cell culture and cellular uptake studies. It is also suitable for use in cell culture to study its effect on a T-helper-1 shift in peripheral blood mononuclear cells (PBMCs) from asthma patients.
Sitostanol may be used in the preparation of binary phospholipid for thermodynamic studies and Brewster angle microscopy studies. It may also be used as a standard steroid in gas chromatography-mass spectrometry(GC-MS).
Biochem/physiol Actions
Plant stanols are structurally similar to cholesterol, hence it reduces the plasma level of LDL cholesterol. Sitostanol is known to possess hypolipidemic and antiatherogenic effects.
Sitostanol decreases cholesterol absorption. Its ratio with cholesterol is implicated in non-alcoholic fatty liver disease (NAFLD). The ratio also correlates with liver steatosis and inflammation. Sitostanol induces interferon γ production and T-helper response in peripheral blood mononuclear cells (PBMC) in asthma patients. It is a hypocholestremic agent as it decreases the micellar solubility and absorption of cholesterol.
Sitostanol lowers the intestinal absorption of cholesterol and serum cholesterol.
Packaging
5 mL Amber Glass Screw Cap Vial (700121P-5mg)
also commonly purchased with this product
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Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
2013 IEEE International Conference on Solid Dielectrics (ICSD) IEEE, 131-131 (2006)
The essential role of cholesterol metabolism in the intracellular survival of Mycobacterium leprae is not coupled to central carbon metabolism and energy production
Journal of Bacteriology, 197(23), 3698-3707 (2015)
Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population
The New England Journal of Medicine, 333(20), 1308-1312 (1995)
Corn fiber oil and sitostanol decrease cholesterol absorption independently of intestinal sterol transporters in hamsters
The Journal of Nutritional Biochemistry, 19(4), 229-236 (2008)
Lipids, 217-217 (1999)
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