700071P
Avanti
24(R)-hydroxycholesterol
Avanti Polar Lipids
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Synonym(s):
5-cholestene-3β,24-diol ; 24-hydroxycholest-5-en-3-ol
Empirical Formula (Hill Notation):
C27H46O2
Recommended Products
description
cholest-5-ene-3β,24(R)-diol
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700071P-1mg)
manufacturer/tradename
Avanti Polar Lipids
shipped in
dry ice
storage temp.
−20°C
General description
24-hydroxycholesterol (24-OH) is an oxidized product of cholesterol. It is synthesized in the presence of enzyme 24S-hydroxylase (CYP46A1).
Biochem/physiol Actions
24(S)-hydroxycholesterol is preferred over 24(R)-hydroxycholesterol by human 7α-hydroxylase. However, the porcine enzyme is active towards both isomers. 24-hydroxycholesterol (24-OH) favors sirtuin 1 expression and reduces the tau protein phosphorylation.
Packaging
5 mL Amber Glass Screw Cap Vial (700071P-1mg)
WGK
WGK 3
Flash Point(F)
No data available
Flash Point(C)
No data available
Certificates of Analysis (COA)
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M Norlin et al.
Journal of lipid research, 41(10), 1629-1639 (2000-10-03)
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this oxysterol. In the
Gabriella Testa et al.
Redox biology, 17, 423-431 (2018-06-09)
It is now established that cholesterol oxidation products (oxysterols) are involved in several events underlying Alzheimer's disease (AD) pathogenesis. Of note, certain oxysterols cause neuron dysfunction and degeneration but, recently, some of them have been shown also to have neuroprotective
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