700027P
Avanti
7α-hydroxy-3-oxo-4-cholestenoic acid
Avanti Polar Lipids
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Synonym(s):
(25R)-cholest-4-en-26-oic acid, 7α-hydroxy-3-oxo
Empirical Formula (Hill Notation):
C27H42O4
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700027P-1mg)
manufacturer/tradename
Avanti Polar Lipids
shipped in
dry ice
storage temp.
−20°C
General description
7α-Hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) is synthesized extrahepatically from cholesterol. The enzyme oxysterols-7α-hydrolase (CYP7B1) acts on precursor 27-hydroxycholesterol (27-OHC) to generate 7-HOCA.. 7-HOCA is catabolized in the liver.
Application
7α-hydroxy-3-oxo-4-cholestenoic acid has been used as an analyte in ultra-high-performance liquid chromatography (UHPLC) system.
Biochem/physiol Actions
The levels of 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) in cerebrospinal fluid are not correlated to neurodegeneration but may serve as a diagnostic marker to trace blood-brain barrier integrity.
Packaging
5 mL Amber Glass Screw Cap Vial (700027P-1mg)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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7 ? -hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier
Saeed A, et al.
Journal of Lipid Research, 55(2), 313-318 (2014)
Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation
Shafaati M, et al.
Journal of Lipid Research, 52(5), 1004-1010 (2011)
Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation
Testa G, et al.
Redox Biology, 10, 24-33 (2016)
Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome
Madenspacher JH, et al.
The Journal of Allergy and Clinical Immunology, 143(1), 440-442 (2019)
Vladimiro Cardenia et al.
Biochimie, 153, 99-108 (2018-08-06)
The electronic cigarettes (e-cigarettes, e-cigs) have become the most sought-after alternative to the traditional cigarettes, partly due to the widespread perception of safety. However, the high temperature reached by e-cig solutions can generate toxic compounds, some of which are listed
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