700014P
Avanti
5β,6β-epoxycholestanol-d7
Avanti Polar Lipids
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Synonym(s):
111115
Empirical Formula (Hill Notation):
C27H39O2D7
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description
cholestanol, 5β,6β-epoxy-d7
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700014P-1mg)
manufacturer/tradename
Avanti Polar Lipids
shipped in
dry ice
storage temp.
−20°C
General description
5β,6β-epoxycholestanol-d7 is the deuterated version of 5β,6β-epoxycholestanol. Cholestanol is a metabolite of cholesterol.
Application
5β,6β-epoxycholestanol-d7 has been used as an internal standard in isotope dilution-mass spectrometry analysis to quantify sterol and oxysterol from mitochondrial samples. It has also been used as an oxysterol standard in high-performance liquid chromatography-mass spectrometry (HPLC-MS method).
Biochem/physiol Actions
Cholestanol levels are elevated in biliary cirrhosis and in cholestasis.
Packaging
5 mL Amber Glass Screw Cap Vial (700014P-1mg)
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Valentin Mutemberezi et al.
Journal of neuroinflammation, 15(1), 74-74 (2018-03-11)
Oxysterols are cholesterol derivatives that have been suggested to play a role in inflammatory diseases such as obesity, atherosclerosis, or neuroinflammatory diseases. However, the effect of neuroinflammation on oxysterol levels has only been partially studied so far. We used an
Julien Musman et al.
Biochemical pharmacology, 142, 87-95 (2017-06-25)
A major cause of cell death during myocardial ischemia-reperfusion is mitochondrial dysfunction. We previously showed that the reperfusion of an ischemic myocardium was associated with an accumulation of cholesterol into mitochondria and a concomitant strong generation of auto-oxidized oxysterols. The
Annika Mutanen et al.
The American journal of clinical nutrition, 100(4), 1085-1094 (2014-08-08)
Increased serum concentrations of plant sterols, including stigmasterol, during parenteral nutrition (PN) have been linked with serum biochemical signs of intestinal failure-associated liver disease (IFALD), whereas clinical data on their correlation to histologic liver injury have been limited. We studied
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