Skip to Content

尊敬的客户：

目前国际形势复杂多变，关税政策尚不明朗，这可能对我们的产品价格产生一定影响。在此情况下，我们希望就订单事宜与您进行友好沟通。

基于当前的不确定性，如果您选择在此期间下单，我们将保留根据实际情况调整价格的权利。同时，我们也理解市场变化可能给您带来的困扰，因此如果在订单实际发货前因关税政策变动导致价格出现较大波动，默克将与您进行协商讨论并视情况对订单进行调整或取消。

Merck
CN
All Photos(2)

Key Documents

View All Documentation

700001P

Avanti

DC-Cholesterol HCl

Avanti Research™ - A Croda Brand 700001P, powder

Synonym(s):

3β-[N-(N′,N′-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride

Sign Into View Organizational & Contract Pricing

Select a Size

25 MG
¥1,319.86
200 MG
¥3,601.49
500 MG
¥6,917.80
1 G
¥11,568.31

¥1,319.86

Available to ship on2025年4月24日Details

Request a Bulk Order
All Photos(2)

Select a Size

Change View
25 MG
¥1,319.86
200 MG
¥3,601.49
500 MG
¥6,917.80
1 G
¥11,568.31

About This Item

Empirical Formula (Hill Notation):
C32H57N2O2Cl
CAS Number:
166023-21-8
Molecular Weight:
537.26
UNSPSC Code:
12352211
NACRES:
NA.25

¥1,319.86

Available to ship on2025年4月24日Details

Request a Bulk Order

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (700001P-1g)
pkg of 1 × 200 mg (700001P-200mg)
pkg of 1 × 25 mg (700001P-25mg)
pkg of 1 × 500 mg (700001P-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 700001P

application(s)

vaccine development

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](C1)(OC(NCC[N+](C)([H])C)=O)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](C)CCCC(C)C.[Cl-]

InChI

1S/C32H56N2O2.ClH/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5;/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35);1H

InChI key

ISXSJGHXHUZXNF-UHFFFAOYSA-N

General description

DC-Cholesterol HCl is a cholesterol derivative and a cationic lipid[1] with a head group and linker moiety.[2]
DC-Cholesterol HCl is a sterol-based transfection reagent.

Application

DC-Cholesterol HCl is suitable:
  • for the preparation of ultrasound cationic microbubbles[3]
  • to prepare liposomes[4]
  • for the preparation of L-glutathione (GSH), loaded proliposomes[5]

DC-Cholesterol HCl may be used in the preparation of colloidal dispersions for transmission electron microscopy studies.[1] It may also be used in liposome preparation for assessing hexokinase activity,[6] poly (lactic-coglycolicacid) loading[7] and in mRNA transfection studies.[8]

Biochem/physiol Actions

DC-Cholesterol is an effective transfection agent and a liposome reagent.[2] Liposome of DC-Cholesterol with dioleoylphosphatidylethanolamine (DOPE) are efficient for DNA transfection.[9] It imparts positive surface charge to the microbubbles for ultra sound based transfection of clustered regularly interspaced short palindromic repeats (CRISPRs).[3]
DC-cholesterol is a cationic lipid, known to be the most efficient in gene transfection study.[10][11]

Packaging

20 mL Clear Glass Screw Cap Vial (700001P-1g)
20 mL Clear Glass Screw Cap Vial (700001P-500mg)
5 mL Amber Glass Screw Cap Vial (700001P-200mg)
5 mL Amber Glass Screw Cap Vial (700001P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number

    It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

    If you need assistance, please contact Customer Support.

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects
    Kommineni N, et al.
    Pharmaceutics, 11(3) (2019)
    Cationic nanoliposomes meet mRNA: efficient delivery of modified mRNA using hemocompatible and stable vectors for therapeutic applications
    Michel T, et al.
    Molecular Therapy, 8, 459-468 (2017)
    Yoshie Maitani et al.
    International journal of pharmaceutics, 342(1-2), 33-39 (2007-06-15)
    Cationic liposomes composed of 3beta-[N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) and dioleoylphosphatidylethanolamine (DOPE) (DC-Chol/DOPE liposome, molar ratio, 1:1 or 3:2) prepared by the dry-film method have been often used as non-viral gene delivery vectors. The formulation and preparation of DC-Chol/DOPE liposomes, as well
    Pharmaceutical Chemistry ? I, 142-142 (2003)
    Cationic liposome (DC-Chol/DOPE= 1: 2) and a modified ethanol injection method to prepare liposomes, increased gene expression
    Maitani Y, et al
    International Journal of Pharmaceutics, 342(1-2), 33-39 (2007)
    View All Related Papers

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service