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699855P

Avanti

3D-(6-acyl) PHAD®

Avanti Polar Lipids

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Synonym(s):
Monophosphoryl Hexa-acyl Lipid A, 3-Deacyl (Synthetic)
Empirical Formula (Hill Notation):
C96H184N3O21P
CAS Number:
252042-59-4
Molecular Weight:
1747.47
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (HPLC)

form

powder

packaging

pkg of 1 × 1 mg (699855P-1mg)
pkg of 1 × 10 mg (699855P-10MG)
pkg of 1 × 10 mg (699855P-25MG)
pkg of 1 × 5 mg (699855P-5mg)

manufacturer/tradename

Avanti Polar Lipids

application(s)

vaccine development

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](O)[C@@H]2NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)[C@@H]2O.[NH4+]

General description

Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD®), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines.

Application

3D-(6-acyl) PHAD® has been used:
  • as a synthetic adjuvant in human papillomavirus (HPV) and virus-like particles (VLPs)-based HPV vaccine preparations
  • as a component of liposomes for immunizing mice with P. falciparum (Pfs25) malaria transmission-blocking vaccine antigen candidate
  • in liposome preparation for the generation of army liposome formulation (ALF) for human immunodeficiency (HIV) gp140 antigen immunization studies in mice

Packaging

2 mL Amber Glass Crimp Cap Vial (699855P-1mg)
2 mL Amber Glass Crimp Cap Vial (699855P-5mg)
5 mL Amber Glass Screw Cap Vial (699855P-10MG);5 mL Amber Glass Screw Cap Vial (699855P-25MG)

Other Notes

For R&D use only. Not for drug, household, or other uses.

Legal Information

PHAD is a registered trademark of Avanti Polar Lipids, Inc.

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Immune response to antigen adsorbed to aluminum hydroxide particles: Effects of co-adsorption of ALF or ALFQ adjuvant to the aluminum-antigen complex
Beck Z, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 275, 12-19 (2018)
A malaria vaccine adjuvant based on recombinant antigen binding to liposomes
Huang WC, et al.
Nature Nanotechnology, 13(12), 1174-1181 (2018)
Shuai Shao et al.
Annals of biomedical engineering (2019-12-14)
A vaccine that induces broadly neutralizing antibodies (bnAbs) against the human immunodeficiency virus (HIV) would be instrumental in controlling the disease. The membrane proximal external region (MPER) peptide is an appealing antigen candidate since it is conserved and is the
Immunogenicity of HPV and HBV vaccines: adjuvanticity of synthetic analogs of monophosphoryl lipid A combined with aluminum hydroxide
Taleghani N, et al.
Acta Pathologica, Microbiologica et Immunological Scandinavica, 127(3), 150-157 (2019)

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