640014P
Avanti
Ceramide Synthase (CerS5/CerS6) Assay Kit
Avanti Polar Lipids
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Synonym(s):
Ceramide Synthase (CerS5/CerS6) Assay Kit, CerS5/S6 Assay Kit
UNSPSC Code:
12161503
Recommended Products
form
powder
usage
sufficient for ~275 reactions
manufacturer/tradename
Avanti Polar Lipids
shipped in
dry ice
storage temp.
−20°C
General description
The CerS Assay Kit provides an easy to use assay for measuring CerS activity in biological samples. This Kit offers the advantage of a short assay time requiring only small amounts of biological material while eliminating TLC as a separation technique with its attendant degradation of NBD sphinganine.
Biochem/physiol Actions
Ceramide synthase (cerS) catalyzes the acylation of sphinganine (dihydrosphingosine) to yield dihydroceramide and sphingosine to yield ceramide. There are six cerS (cerS1-6), which differ in their specificity to yield ceramides of different chain length. Ceramide is a key intermediate in sphingolipid metabolism and an key signaling molecule.
Packaging
Kit contains:
0.3mg 16:0 fatty acyl-CoA
0.1mg NBD Sphinganine
0.3mg 16:0 fatty acyl-CoA
0.1mg NBD Sphinganine
Storage and Stability
Note: this product should be stored at -20° for up to 6 months.
Regulatory Information
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Certificates of Analysis (COA)
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The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.
Hartmann D, et al.
The International Journal of Biochemistry & Cell Biology, 45(7), 1195-1203 (2013)
When do Lasses (longevity assurance genes) become CerS (ceramide synthases)? Insights into the regulation of ceramide synthesis.
Pewzner-Jung Y, et al.
The Journal of Biological Chemistry, 281(35), 25001-25005 (2006)
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