330001S
Avanti
E06 mAb
E06 Mouse Monoclonal Antibody (IgM), Anti-(Oxidized Phospholipid), 1X PBS (Phosphate Buffered Saline) with 0.27 mM Na2 EDTA
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Synonym(s):
E06 mAb, T15 antibody
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
Assay
>95%
form
solution
packaging
pkg of 1 × 0.1 mL (polypropylene tube with screw cap (330001S-100ug))
manufacturer/tradename
Avanti Polar Lipids 330001S
concentration
1 mg/mL (330001S-100ug)
shipped in
dry ice
storage temp.
−70°C
General description
The E06 antibody is a murine monoclonal IgM natural antibody that binds to oxidized phospholipid and reacts with oxidized LDL, oxidized HDL and protein covalently modified by oxidized phospholipid. Each batch is verified for activity and provided with detailed protocols for the above applications.The E06 antibody was developed by Dr. Joseph Witztum at the University of California, San Diego using apolipoprotein E knock-out mice fed a high-fat diet for seven months.
Application
E06 mAb has been used as a marker to detect oxidative injury.
The E06 antibody has been used to probe atherosclerotic plaque in mice, zebrafish, rabbits, monkeys and humans. It also binds to apoptotic cells, but not viable cells, and can be used in a variety of applications, including ELISA, immunohistochemistry and Western blot analysis, as well as for in vivo imaging with MRI techniques.
Packaging
0.5 mL Polypropylene Tube with Screw Cap (330001S-100ug)
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models
Schuh C, et al.
Acta Neuropathologica, 128(2), 247-266 (2014)
Arnab Chattopadhyay et al.
Journal of lipid research, 57(5), 832-847 (2016-03-12)
Mouse chow supplemented with lysophosphatidylcholine with oleic acid at sn-1 and a hydroxyl group at sn-2 (LysoPC 18:1) increased LysoPC 18:1 in tissue of the jejunum of LDL receptor (LDLR)-null mice by 8.9 ± 1.7-fold compared with chow alone. Western
Sotirios Tsimikas et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(1), 175-181 (2006-11-04)
Oxidized phospholipids (OxPL) are pro-inflammatory. We evaluated whether changes in plasma levels of OxPL associated with apolipoprotein B-100 (apoB-100) reflect changes in OxPL content in atherosclerotic plaques during dietary-induced atherosclerosis progression and regression. OxPL content was measured in plasma and
Peter Friedman et al.
The Journal of biological chemistry, 277(9), 7010-7020 (2001-12-18)
The oxidation of low density lipoproteins (LDL) has been correlated with atherogenesis through a variety of pathways. The process involves nonspecific fragmentation, oxidative breakdown, and modification of the lipids and protein of LDL. The process yields a variety of bioactive
J Qin et al.
Journal of neuroscience research, 85(5), 977-984 (2007-02-17)
Multiple sclerosis (MS) is a common autoimmune neurodegenerative disease of unknown cause, which results in inflammation and plaques of demyelination in brain and eventual axonal degeneration. We report the novel presence of oxidized phosphatidylcholine [1-palmitoyl-2-(5'-oxo)valeryl-sn-glycero-3-phosphorylcholine (POVPC)], a lipid associated with
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