Skip to Content
Merck
CN
All Photos(3)

Documents

Safety Information

131305P

Avanti

Sulfatides (Brain)

Avanti Research™ - A Croda Brand

Synonym(s):

Cerebroside sulfates; Mono-Sulfo Galactosyl(β) Ceramide  (d18:1/24:0); 3-O-sulfo-β-D-C24-galactosylceramide (ammonium salt)

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

CAS Number:
383906-24-9
UNSPSC Code:
12352211
NACRES:
NA.25

description

Sulfatides (Brain, Porcine) (ammonium salt)

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (131305P-10mg)
pkg of 1 × 25 mg (131305P-25mg)
pkg of 1 × 5 mg (131305P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](OS([O-])(=O)=O)[C@H]([C@H]1CO)O.[NH4+]

General description

Sulfatides are majorly present in the brain and plasma membrane, especially in the outer leaflet. They are anionic sulfoglycolipids synthesized by oligodendrocytes and are the prime component of myelin sheath. It constitutes 4 -7% weight of the myelin lipid. Sulfatides are also associated with non-neural tissues including gall bladder, colon and kidney. In the Golgi, 3′-phosphoadenosine5′phosphosulfate:cerebrosidesulfo transferase mediates the synthesis of sulfatides by 3-O-sulfation of the galactosylceramide. Lysosomes are the catabolism site for sulfatides, wherein arylsulfatase A mediates their breakdown.
This Natural Lipid is a mixture, and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.

Application

Sulfatides (Brain) has been used:
  • as a lipid standard in electrospray ionization (ESI)-MS/MS analysis, as an anionic amphiphile for large unilamellar vesicles (LUVs) preparation
  • to test its myelin-associated axon growth inhibition functionality in retinal ganglion cells
  • as a calibrant in tandem mass spectrometry to quantify mouse brain myelin samples

Biochem/physiol Actions

Elevated sulfatides levels are implicated in renal, ovarian and adenocarcinoma. Accumulation of sulfatides in events of arylsulfatase A enzyme deficiency leads to metachromatic leukodystrophy, a lysosomal storage disease. Sulfatide is a myelin-associated inhibitor of axon growth and is implicated in the axon regenerative failure. It is a multifunctional sulfolipid, which plays a key role in immune response and insulin secretion. It binds to fibrinogen and elicits anticoagulant activity. Sulfatides are elevated in Parkinson′s disease and is a target for nervous disorder treatment. Sulfatideis also an inhibitor of oligodendrocyte differentiation. Sulfatides are utilized by bacteria for their adherence into host cells. They are responsible for the inflammatory responses in chronic central nervous system illness.

Packaging

5 mL Amber Glass Screw Cap Vial (131305P-10mg)
5 mL Amber Glass Screw Cap Vial (131305P-25mg)
5 mL Amber Glass Screw Cap Vial (131305P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Reproduction of vesicles coupled with a vesicle surface-confined enzymatic polymerisation
Kurisu M, et al.
Communications Chemistry, 2(1), 1-10 (2019)
A comprehensive profiling of sulfatides in myelin from mouse brain using liquid chromatography coupled to high-resolution accurate tandem mass spectrometry
Pintado-Sierra M, et al.
Analytica Chimica Acta, 951(1), 89-98 (2017)
Prosaposin deficiency and saposin B deficiency (activator-deficient metachromatic leukodystrophy): report on two patients detected by analysis of urinary sphingolipids and carrying novel PSAP gene mutations
Kuchar L, et al.
American Journal of Medical Genetics. Part A, 149(4), 613-621 (2009)
Role of sulfatide in normal and pathological cells and tissues
Takahashi T and Suzuki T
Journal of Lipid Research, 53(8), 1437-1450 (2012)
Sulfatide, a major lipid component of myelin sheath, activates inflammatory responses as an endogenous stimulator in brain-resident immune cells
Jeon SB, et al
Journal of Immunology, 181(11), 8077-8087 (2008)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service