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Merck
CN

W320404

4-Methyl-5-thiazoleethanol

≥98%, FG

Synonym(s):

5-(2-Hydroxyethyl)-4-methylthiazole, Sulfurol

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About This Item

Empirical Formula (Hill Notation):
C6H9NOS
CAS Number:
137-00-8
Molecular Weight:
143.21
FEMA Number:
3204
Council of Europe no.:
11621
UNSPSC Code:
12164502
PubChem Substance ID:
24901552
Flavis number:
15.014
EC Number:
205-272-6
NACRES:
NA.21
MDL number:
MFCD00005339
Beilstein/REAXYS Number:
114249
Organoleptic:
fatty; meaty; nutty
Grade:
FG, Fragrance grade, Halal, Kosher
Biological source:
synthetic
Agency:
follows IFRA guidelines, meets purity specifications of JECFA
Food allergen:
no known allergens

Key Documents

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SMILES string

Cc1ncsc1CCO

InChI

1S/C6H9NOS/c1-5-6(2-3-8)9-4-7-5/h4,8H,2-3H2,1H3

InChI key

BKAWJIRCKVUVED-UHFFFAOYSA-N

biological source

synthetic

grade

FG, Fragrance grade, Halal, Kosher

agency

follows IFRA guidelines, meets purity specifications of JECFA

reg. compliance

EU Regulation 1223/2009, EU Regulation 1334/2008 & 178/2002

assay

≥98%

Quality Level

300, 400

refractive index

n20/D 1.550 (lit.)

bp

135 °C/7 mmHg (lit.)

density

1.196 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

fragrance allergen

no known allergens

organoleptic

fatty; meaty; nutty

storage temp.

room temp

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Related Categories

General description

4-Methyl-5-thiazoleethanol is a sulfur-containing heterocyclic flavor compound that is reported to occur in Comté cheese and Panax ginseng.

Application


  • New aspects characterizing non-obese NAFLD by the analysis of the intestinal flora and metabolites using a mouse model.: This study explores the metabolic pathways affected by non-obese NAFLD, highlighting the role of 4-Methyl-5-thiazoleethanol in modulating gut microbiota and its potential as a therapeutic marker (Zhang et al., 2024).

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

233.6 °F - closed cup

flash_point_c

112 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS8738
SHBS7912
SHBR5285
SHBR4587
SHBS2564

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A thiazole and two β-carboline constitutents from Panax ginseng.
Park JD, et al.
Archives of Pharmacal Research, 11(1), 52-55 (1988)
Flavor constituents of aqueous fraction extracted from Comte cheese by liquid carbon dioxide.
Roudot?Algaron F, et al.
Journal of Food Science, 58(5), 1005-1009 (1993)
H Nishimura et al.
Journal of bacteriology, 174(14), 4701-4706 (1992-07-01)
We have isolated a thiamine auxotrophic mutant carrying a recessive mutation which lacks the positive regulatory gene, THI3, which differs in the regulation of thiamine transport from the THI2 (PHO6) gene described previously (Y. Kawasaki, K. Nosaka, Y. Kaneko, H.
L B Filippova et al.
Voprosy meditsinskoi khimii, 26(5), 643-646 (1980-09-01)
35S-Hemineurine penetrated across the blood-brain barrier more rapidly than 35S-thiamin within the first 30 min after intravenous administration. Within 24 hrs content of 35S-thiamin in the neurones exceeded by 34% its concentration in glia and by 200% -- in myelin
E Webb et al.
Journal of bacteriology, 179(13), 4399-4402 (1997-07-01)
Thiamine pyrophosphate (TPP) is a required cofactor in Salmonella typhimurium that is generated de novo by the condensation of 4-amino-5-hydroxymethyl pyrimidine (HMP) pyrophosphate and 4-methyl-5-(beta-hydroxyethyl)-thiazole (THZ) monophosphate. The THZ and HMP moieties are independently synthesized, and labeling studies have demonstrated
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