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W294004

Sigma-Aldrich

Propylene glycol

≥99.5% (GC), FCC, FG

Synonym(s):

1,2-Propanediol, Propylene glycol

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About This Item

Linear Formula:
CH3CH(OH)CH2OH
CAS Number:
57-55-6
Molecular Weight:
76.09
FEMA Number:
2940
Beilstein:
1340498
EC Number:
200-338-0
Council of Europe no.:
4212
MDL number:
MFCD00064272
UNSPSC Code:
12164502
PubChem Substance ID:
24901410
NACRES:
NA.21

biological source

synthetic

Quality Level

400

grade

FG
Fragrance grade
Halal
Kosher

Agency

follows IFRA guidelines

reg. compliance

EU Regulation 1223/2009
EU Regulation 1334/2008 & 178/2002
FCC
FDA 21 CFR 175.300
FDA 21 CFR 175.320
FDA 21 CFR 176.180
FDA 21 CFR 176.210
FDA 21 CFR 184.1666

vapor density

2.62 (vs air)

vapor pressure

0.08 mmHg ( 20 °C)

Assay

≥99.5% (GC)

form

viscous liquid

autoignition temp.

779 °F

expl. lim.

12.5 %

refractive index

n20/D 1.432 (lit.)

bp

187 °C (lit.)

mp

−60 °C (lit.)

density

1.036 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

fragrance allergen

no known allergens

Organoleptic

odorless

SMILES string

CC(O)CO

InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

InChI key

DNIAPMSPPWPWGF-UHFFFAOYSA-N

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General description

Propylene glycol is an aliphatic dihydric alcohol with a wide range of applications in the food industry such as an anticaking agent, antioxidant, humectant, flavoring agent, emulsifier, stabilizer, thickener etc.

Application


  • Fatally impaired glucose digestion by propylene glycol in Aedes aegypti (Diptera: Culicidae) and co-formulation with terpenoids for enhancing attractive toxic sugar baits.: This study explores the application of propylene glycol in impairing glucose digestion in mosquitoes, offering a novel approach to vector control through enhanced toxic sugar baits. The synergy with terpenoids broadens its impact, marking significant progress in pest management strategies (Maes et al., 2024).

  • Null cross-modal effects of olfactory training on visual, auditory or olfactory working memory in 6- to 9-year-old children.: This neuroscientific study utilizes propylene glycol in olfactory training exercises, investigating its potential to influence cross-modal sensory processing. Despite null findings, it provides a critical assessment of sensory integration therapies (Pieniak et al., 2024).

  • Propylene glycol toxicity in an adolescent secondary to chronic cornstarch ingestion.: This medical case study addresses the risks associated with excessive propylene glycol intake, highlighting its potential toxic effects. The study serves as a crucial reminder of the need for regulatory scrutiny and public awareness regarding chemical additives in food products (Downey et al., 2024).

WGK

WGK 3

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Handbook of Preservatives, 508-508 (2004)
Encyclopedia of Food and Color Additives, 2, 2347-2347 (1997)
Bahareh Eftekharzadeh et al.
Nature communications, 10(1), 3562-3562 (2019-08-10)
Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens, enabling transactivation and causing the receptor to become aggregation-prone. Here we show that these molecular chaperones
Saiful E Syafruddin et al.
Nature communications, 10(1), 1152-1152 (2019-03-13)
Transcriptional networks are critical for the establishment of tissue-specific cellular states in health and disease, including cancer. Yet, the transcriptional circuits that control carcinogenesis remain poorly understood. Here we report that Kruppel like factor 6 (KLF6), a transcription factor of
Gai Ling Li et al.
Journal of controlled release : official journal of the Controlled Release Society, 84(1-2), 49-57 (2002-10-26)
To achieve a therapeutical effect of the anti-Parkinson's drug R-apomorphine via iontophoresis delivery, enhancement strategies in vitro were explored using three structurally related enhancers, lauric acid (LA), dodecyltrimethylammonium bromide (DTAB) and Laureth-3 oxyethylene ether (C(12)EO(3)). Human stratum corneum and shed
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