All Photos(1)
Synonym(s):
Menthol, 2-Isopropyl-5-methylcyclohexanol, Hexahydrothymol
Empirical Formula (Hill Notation):
C10H20O
CAS Number:
Molecular Weight:
156.27
FEMA Number:
2665
Beilstein:
3194263
EC Number:
Council of Europe no.:
63
MDL number:
UNSPSC Code:
12164502
PubChem Substance ID:
Flavis number:
2.015
NACRES:
NA.21
Recommended Products
biological source
synthetic
Quality Level
grade
FG
Halal
Kosher
reg. compliance
EU Regulation 1334/2008 & 178/2002
FCC
FDA 21 CFR 117
FDA 21 CFR 172.515
vapor pressure
0.8 mmHg ( 20 °C)
Assay
≥95%
bp
216 °C (lit.)
mp
34-36 °C (lit.)
density
0.89 g/mL at 25 °C (lit.)
application(s)
flavors and fragrances
Documentation
see Safety & Documentation for available documents
food allergen
no known allergens
Organoleptic
woody; minty; cooling
SMILES string
CC(C)C1CCC(C)CC1O
InChI
1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3
InChI key
NOOLISFMXDJSKH-UHFFFAOYSA-N
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General description
DL-Menthol is a racemic mixture of D- and L-menthol. Its optical resolution produces L-menthol, which is widely used in confectionaries cosmetics and toothpaste for its characteristic peppermint flavor and cooling effect.
Application
- Developing of an eco-friendly liquid-liquid microextraction method by using menthol-based hydrophobic deep eutectic solvent for determination of basic fuchsin dye: assessment of the greenness profile.: This study introduces a sustainable method using DL-menthol-based solvents for extracting and analyzing industrial dyes, providing a green alternative to traditional solvent extraction techniques (Aydin et al., 2024).
- Potential fumigant toxicity of essential oils against Sitotroga cerealella (Olivier) (Lepidoptera: Gelechiidae) and its egg parasitoid Trichogramma evanescens (Hymenoptera: Trichogrammatidae).: This research highlights the efficacy of DL-menthol in pest management, examining its potential as a natural fumigant that could replace synthetic chemicals in agricultural practices (Elbehery et al., 2024).
- Differential analysis of volatiles in five types of mosquito-repellent products by chemometrics combined with headspace GC-Orbitrap HRMS nontargeted detection.: Explores the application of DL-menthol in developing mosquito-repellent formulations, enhancing the understanding of volatile compounds in public health products (Zhao et al., 2024).
- Vortex-assisted dispersive liquid-liquid microextraction based on the hydrophobic deep eutectic solvent-based ferrofluid for extraction and detection of myclobutanil.: Utilizes DL-menthol in innovative extraction methods for pesticide analysis, promoting safer and more efficient detection techniques in food safety and environmental monitoring (Fattahi et al., 2023).
Biochem/physiol Actions
Taste at 25 ppm
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
WGK
WGK 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Lucie Percevault et al.
The journal of physical chemistry. B, 124(41), 9126-9135 (2020-09-19)
We have performed small-angle neutron scattering in a momentum transfer range (0.05 < Q < 0.5 Å-1) to study long-range order and concentration fluctuations in deep eutectic solvents (DESs) and their aqueous solutions. Ethaline (choline chloride/ethylene glycol), glycerol/lactic acid, and
Andrea C Villanti et al.
American journal of preventive medicine, 44(4), 388-391 (2013-03-19)
Passage of the U.S. Family Smoking Prevention and Tobacco Control Act in 2009 led to a ban on the sale of flavored cigarettes, largely because of studies showing targeting of these products to youth and young adults. There are no
Yang Chen et al.
International journal of pharmaceutics, 443(1-2), 120-127 (2013-01-22)
To explore the structure-activity relationship for terpenes as transdermal penetration enhancers, unsaturated menthol analogues were synthesized in our study, including p-menth-1-en-3-ol (Compd 1), p-menth-4-en-3-ol (Compd 2), p-menth-4(8)-en-3-ol (Compd 3) and p-menth-8-en-3-ol (Compd 4). Their enhancing activity on the penetration of
Andrew A Strasser et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 22(3), 382-389 (2013-01-22)
As part of the Family Smoking Prevention and Tobacco Control Act, the U.S. Food and Drug Administration charged the Tobacco Products Scientific Advisory Committee with developing a report and recommendations about the effect of menthol in cigarettes on the public
María Ll Valero et al.
PloS one, 7(12), e51825-e51825 (2012-12-20)
Overexpression of the cation-permeable channel TRPM8 in prostate cancers might represent a novel opportunity for their treatment. Inhibitors of TRPM8 reduce the growth of prostate cancer cells. We have used two recently described and highly specific blockers, AMTB and JNJ41876666
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