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W256900

Sigma-Aldrich

α-Hexylcinnamaldehyde

≥95%, stabilized, FG

Synonym(s):

Hexyl cinnamic aldehyde

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About This Item

Linear Formula:
C6H5CH=C[(CH2)5CH3]CHO
CAS Number:
101-86-0
Molecular Weight:
216.32
FEMA Number:
2569
Council of Europe no.:
129
MDL number:
MFCD00006989
UNSPSC Code:
12164502
PubChem Substance ID:
24901162
Flavis number:
5.041
NACRES:
NA.21

biological source

synthetic

Quality Level

400

grade

FG
Fragrance grade
Halal
Kosher

Agency

follows IFRA guidelines

reg. compliance

EU Regulation 1223/2009
EU Regulation 1334/2008 & 178/2002
FDA 21 CFR 117
FDA 21 CFR 172.515

Assay

≥95%

contains

0.075-0.500% BHT as stabilizer

composition

Contains IFRA and EU1223/2009 α-Hexylcinnamaldehyde

refractive index

n20/D 1.55 (lit.)

bp

174-176 °C/15 mmHg (lit.)

density

0.95 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

fragrance allergen

α-Hexylcinnamaldehyde

Organoleptic

green; floral; sweet

SMILES string

[H]C(=O)\C(CCCCCC)=C\c1ccccc1

InChI

1S/C15H20O/c1-2-3-4-6-11-15(13-16)12-14-9-7-5-8-10-14/h5,7-10,12-13H,2-4,6,11H2,1H3/b15-12+

InChI key

GUUHFMWKWLOQMM-NTCAYCPXSA-N

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General description

α-Hexylcinnamaldehyde is commonly used as a flavoring and fragrance ingredient. It shows potential chemosensitizing properties.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H317,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 2 - Skin Sens. 1

WGK

WGK 2

Flash Point(F)

235.4 °F

Flash Point(C)

113 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zhen Liu et al.
Wei sheng yan jiu = Journal of hygiene research, 38(5), 585-589 (2009-11-03)
To improve the local lymph node assay (LLNA) as an alternative method to detect chemicals for both sensitization and irritation. The following chemicals: one negative control: 4-Aminobenzoic Acid, three sensitizers: 2,4-dinitrochlorobenzene (DNCB), Hexyl cinnamic aldehyde (HCA), 2-Aminophenol (2-APC) and two
R J Dearman et al.
Journal of applied toxicology : JAT, 18(4), 281-284 (1998-08-27)
The local lymph node assay is an alternative method for the prospective identification of chemicals that have the potential to cause skin sensitization. Activity in the assay is measured as a function of proliferative responses by draining lymph node cells
Y Nakamura et al.
The Journal of toxicological sciences, 23(2), 105-111 (1998-06-30)
Both male and female guinea pigs are widely used in tests to detect the skin-sensitizing potential of new chemicals. The aim of the present study was to investigate the influence of the animal gender on sensitization rates, with the guinea-pig
?-Hexylcinnamaldehyde Synergistically Increases Doxorubicin Cytotoxicity Towards Human Cancer Cell Lines.
Di Giacomo S, et al.
Anticancer Research, 36(7), 3347-3351 (2016)
Darrell R Boverhof et al.
Toxicological sciences : an official journal of the Society of Toxicology, 105(1), 79-85 (2008-06-17)
The mouse local lymph node assay (LLNA) has become the preferred test for evaluating the dermal sensitization potential of chemicals and requirements are now emerging for its use in the evaluation of their formulated products, especially in the European Union.
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