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QBD10009

Sigma-Aldrich

Biotin-dPEG®4-TFP ester

Synonym(s):

Polyethylene glycol

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About This Item

Empirical Formula (Hill Notation):
C27H37F4N3O8S
Molecular Weight:
639.66
UNSPSC Code:
12352108
PubChem Substance ID:
329823873
NACRES:
NA.22

Assay

>90%

form

solid or viscous liquid

reaction suitability

reaction type: Biotinylations
reaction type: Biotinylations
reactivity: amine reactive
reagent type: cross-linking reagent

polymer architecture

shape: linear
functionality: monofunctional

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(CCCCC1SCC(N2)C1NC2=O)NCCOCCOCCOCCOCCC(OC3=C(C(F)=CC(F)=C3F)F)=O

Related Categories

Application

Biotin-dPEG®4-TFP ester is an amphiphilic and hydrolytically stable compound used as a cross-linking reagent in biotinylations reactions.

Features and Benefits

Biotin-dPEG®4-TFP ester has 2,3,5,6-tetrafluorophenyl (TFP) moiety which hydrolyzes more slowly than NHS ester in aqueous media and are more reactive towards amines than NHS esters. The single molecular weight Biotin-dPEG®4-TFP ester has a long spacer of precise length (19.2 Å) between the biotin moiety and the labeled molecule. This dPEG spacer imparts a high degree of water solubility to the biotin label. The PEG spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Bioconjugate techniques
Bioconjugate Techniques (2013)

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