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Merck
CN

P9906

Poly(ethylene glycol) bis(amine)

average MN 3,400, cross-linking reagent carboxyl reactive, amine

Synonym(s):

Polyethylene glycol, O,O′-Bis(2-aminoethyl)polyethylene glycol, Diaminopolyethylene glycol, PEG-diamine, Polyoxyethylene bis(amine)

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About This Item

Linear Formula:
H2N(CH2CH2O)nCH2CH2NH2
CAS Number:
24991-53-5
UNSPSC Code:
12162002
PubChem Substance ID:
24898931
NACRES:
NA.23
MDL number:
MFCD00132004

Key Documents

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Product Name

Poly(ethylene glycol) bis(amine), average Mn 3400

SMILES string

NCCOCCOCCN

InChI

1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2

InChI key

IWBOPFCKHIJFMS-UHFFFAOYSA-N

form

powder

mol wt

average Mn 3400

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

Ω-end

amine

α-end

amine

polymer architecture

shape: linear
functionality: homobifunctional

storage temp.

2-8°C

Quality Level

200

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Application

Poly(ethylene glycol) bis(amine) may be used in the preparation of folic acid-PEG-NH2 conjugate. PEG-bis(amine) has been reported to be used as a component in the making of Au-Fe2O3 NPs based multifunctional nanoprobe for multimodal and ultrasensitive detection of cancer cells.

Preparation Note

Prepared from PEG with an average molecular weight of 3,350

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000503938
0000503937
0000503937
0000503938
0000426787

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Evaluation of receptor mediated endocytosis on cellular internalization: a comparative study of pegylated nanoparticles and folate anchored pegylated nanoparticles on mda-mb-231 cells
Mahalwar A, et al.,
International Journal of Biological & Pharmaceutical Research null
Development and characterization of folate targeted nanoparticle drug delivery system
mittal V, et al.
International Journal of Pharmacy and Biological Sciences, V1(2) (2010)
Jian Liu et al.
Chemical communications (Cambridge, England), 49(43), 4938-4940 (2013-04-23)
A multifunctional nanoprobe, which can be used for dual modal imaging and the detection of cancer cells, has been reported.
Development and characterization of folate targeted nanoparticle drug delivery system
Mittal V, et al.
International Journal of Pharmacy and Biological Sciences, V1(2) (2000)
Alison G Patrick et al.
Macromolecular bioscience, 10(10), 1184-1193 (2010-07-02)
The design of hydrogels that simultaneously report protease activity and remove excess protease from solution is elucidated. The hydrogels, based on amino-PEGA, combine enzyme-specific peptides flanked with FRET complimented by charged amino acid residues that facilitate protease uptake via short
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