P1781
Pteroic acid
≥93%
Synonym(s):
4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid
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About This Item
Empirical Formula (Hill Notation):
C14H12N6O3
CAS Number:
Molecular Weight:
312.28
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Assay:
≥93%
Form:
powder
InChI
1S/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)
SMILES string
NC1=NC(=O)C2=NC(CNc3ccc(cc3)C(O)=O)=CNC2=N1
InChI key
JOAQINSXLLMRCV-UHFFFAOYSA-N
assay
≥93%
form
powder
Quality Level
Application
Pteroic acid can be used as a reactant to synthesize:
- N-trifluoroacetyl pteroic acid by reacting with trifluoroacetic anhydride via acylation.
- bis-Decyl chain derivative of pteroic acid through photocleavage reaction.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Maciej Adamczyk et al.
Bioorganic & medicinal chemistry letters, 14(9), 2313-2317 (2004-04-15)
N(10)-Trifluoroacetylpteroic acid was conjugated to chemiluminescent N-sulfonylacridinium-9-carboxamide labels at the N(10) or 9-position carboxamide. Upon binding to folate binding protein the light output of the N(10) derivative (9) was quenched up to 62% upon triggering with basic peroxide, while the
H Oe et al.
Journal of nutritional science and vitaminology, 29(5), 523-531 (1983-10-01)
A sensitive radioassay method has been developed to quantitate the activity of the folate-hydrolyzing enzyme which catalyzes the hydrolysis of folic acid to pteroic acid and glutamic acid. The method is based on analyzing [2-14C]pteroic acid separated by a thin-layer
Kerim Babaoglu et al.
Structure (London, England : 1993), 12(9), 1705-1717 (2004-09-03)
Dihydropterate synthase (DHPS) is the target for the sulfonamide class of antibiotics, but increasing resistance has encouraged the development of new therapeutic agents against this enzyme. One approach is to identify molecules that occupy the pterin binding pocket which is
H S Tillinghast et al.
Journal of cell science, 87 ( Pt 1), 45-53 (1987-02-01)
Following a previous study indicating a sensitivity to folate during the developmental phase of Dictyostelium discoideum, a series of pteridines were investigated for their ability to induce amoebal chemotaxis during development of this organism. Several compounds were found to resemble
Application of halogeno-ketones to the synthesis of pteridines, including pteroic acid.
F E KING et al.
Nature, 164(4170), 574-574 (1949-10-01)
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