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N8141

Sigma-Aldrich

4-Nitroquinoline N-oxide

≥98%

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Synonym(s):
4-NQO, 4-Nitroquinoline 1-oxide
Empirical Formula (Hill Notation):
C9H6N2O3
CAS Number:
56-57-5
Molecular Weight:
190.16
Beilstein:
165756
EC Number:
200-281-1
MDL number:
MFCD00006738
UNSPSC Code:
12352100
PubChem Substance ID:
57654464
NACRES:
NA.22

Assay

≥98%

color

yellow to brown

mp

154-156 °C (lit.)

solubility

acetone: soluble, clear to hazy

storage temp.

−20°C

SMILES string

[O-][N+](=O)c1cc[n+]([O-])c2ccccc12

InChI

1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H

InChI key

YHQDZJICGQWFHK-UHFFFAOYSA-N

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General description

4-Nitroquinoline N-oxide is a quinoline derivative widely used in chemical research and development.

Application

4-Nitroquinoline N-oxide has been used as a model compound to study its carcinogenic effects.

Biochem/physiol Actions

Skin and lung tumor initiator under experimental conditions.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H350

Hazard Classifications

Carc. 1B

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Ye Du et al.
Environment international, 135, 105369-105369 (2019-12-17)
Effluents from wastewater treatment plants (WWTPs) may contain various pollutants with potential toxic effects. Ozonation is widely applied to purify wastewater, which may influence the toxicity and water quality indices simultaneously. The main goal of this study was to reveal
Interplay of DNA repair, homologous recombination, and DNA polymerases in resistance to the DNA damaging agent 4-nitroquinoline-1-oxide in Escherichia coli.
Williams AB, et al.
DNA Repair, 9(10), 1090-1097 (2010)
Antitumor activity of ficus deltoidea extract on oral cancer: An in vivo study
Al-Koshab M, et al.
Journal of Oncology, 2020 (2020)
The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO-and t-BOOH-induced mutagenesis in coli.
Nikolic B, et al.
Archives of Biological Sciences, 63(1), 117-128 (2011)
Francesca Trotta et al.
International journal of food microbiology, 153(3), 275-280 (2011-12-20)
Yeasts isolated from Italian beverages and foods (wine and cheeses) were identified as Saccharomyces cerevisiae and Debaryomyces hansenii by sequencing the D1/D2 domain of the 26S rRNA gene and differentiated, at strain level, by microsatellite PCR fingerprinting and RAPD-PCR. All
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