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G6503

Sigma-Aldrich

Glycine ethyl ester hydrochloride

99%, for peptide synthesis

Synonym(s):

GEE, Ethyl glycinate hydrochloride

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About This Item

Linear Formula:
NH2CH2COOC2H5 · HCl
CAS Number:
623-33-6
Molecular Weight:
139.58
Beilstein:
3594034
EC Number:
210-787-4
MDL number:
MFCD00012871
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24895258
NACRES:
NA.22

product name

Glycine ethyl ester hydrochloride, 99%

Quality Level

200

Assay

99%

form

powder or chunks

reaction suitability

reaction type: solution phase peptide synthesis

technique(s)

drug transporter assay: suitable

color

white

mp

145-146 °C (lit.)

application(s)

peptide synthesis

SMILES string

Cl.CCOC(=O)CN

InChI

1S/C4H9NO2.ClH/c1-2-7-4(6)3-5;/h2-3,5H2,1H3;1H

InChI key

TXTWXQXDMWILOF-UHFFFAOYSA-N

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Application

Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) for carboxyl-footprinting studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zhang, H.; et al.
Molecular and Cellular Proteomics, 10 (2011)
Hao Zhang et al.
International journal of mass spectrometry, 312, 78-86 (2012-03-13)
Protein structure determines function in biology, and a variety of approaches have been employed to obtain structural information about proteins. Mass spectrometry-based protein footprinting is one fast-growing approach. One labeling-based footprinting approach is the use of a water-soluble carbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
Karen Leffondre et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(8), 1237-1243 (2014-10-19)
The most commonly used methods to investigate risk factors associated with renal function trajectory over time include linear regression on individual glomerular filtration rate (GFR) slopes, linear mixed models and generalized estimating equations (GEEs). The objective of this study was
Paula Gonzalez et al.
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The Costa Rica Vaccine Trial (CVT) was a randomized clinical trial conducted between 2004 and 2010, which randomized 7466 women aged 18 to 25 to receive the bivalent HPV-16/18 vaccine or control Hepatitis-A vaccine. Participants were followed for 4 years
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Choice egg-count bioassays are a popular tool for analysing oviposition substrate preferences of gravid mosquitoes. This study aimed at improving the design of two-choice experiments for measuring oviposition substrates preferences of the malaria vector Anopheles gambiae senso lato, a mosquito
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