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E4550

Sigma-Aldrich

Diethylene glycol monoethyl ether

≥99%

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Synonym(s):
2-(2-Ethoxyethoxy)ethanol, CARBITOL™, Diethylene glycol ethyl ether, Ethyldiglycol
Linear Formula:
C2H5OCH2CH2OCH2CH2OH
CAS Number:
111-90-0
Molecular Weight:
134.17
Beilstein:
1736441
EC Number:
203-919-7
MDL number:
MFCD00002872
UNSPSC Code:
12352112
PubChem Substance ID:
329799059
NACRES:
NA.21

vapor density

4.63 (vs air)

Quality Level

200

vapor pressure

0.12 mmHg ( 20 °C)

Assay

≥99%

form

liquid

expl. lim.

1.2 %, 135 °F
23.5 %, 182 °F

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.427 (lit.)

bp

202 °C (lit.)

mp

-80 °C (lit.)

density

0.999 g/mL at 25 °C (lit.)

SMILES string

CCOCCOCCO

InChI

1S/C6H14O3/c1-2-8-5-6-9-4-3-7/h7H,2-6H2,1H3

InChI key

XXJWXESWEXIICW-UHFFFAOYSA-N

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Legal Information

CARBITOL is a trademark of The Dow Chemical Company or an affiliated company of Dow

WGK

WGK 1

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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J-L Delongeas et al.
Regulatory toxicology and pharmacology : RTP, 57(2-3), 284-290 (2010-03-30)
Drug safety research is frequently faced with the challenge of the selection of appropriate vehicles for use in in vivo non-clinical safety assessment studies. Reported here are the results of blend Labrasol, Labrafil and Transcutol, [L/L/T, (4/4/2, v/v/v)], excipients used
Rania M Hathout et al.
Molecular pharmaceutics, 7(4), 1266-1273 (2010-06-16)
This research determined the uptake of individual components of topically applied microemulsions into the stratum corneum (SC) and assessed their molecular effects on skin barrier function. The microemulsions comprised oleic acid, Tween20, Transcutol and water. The effects of selected formulations
Maria Manconi et al.
International journal of pharmaceutics, 412(1-2), 37-46 (2011-05-03)
The ability of a recently developed novel class of liposomes to promote dermal delivery of tretinoin (TRA) was evaluated. New penetration enhancer-containing vesicles (PEVs) were prepared adding to conventional phosphatidylcholine vesicles (control liposomes) different hydrophilic penetration enhancers: Oramix NS10 (OrNS10)
Jeoung Hee Yoo et al.
Archives of pharmacal research, 33(3), 417-426 (2010-04-03)
Self-nanoemulsifying drug delivery system (SNEDDS) containing oil (Phosal 53 MCT), surfactant (Labrasol), and cosurfactant (Transcutol-HP or Lutrol-E400) was prepared to enhance solubility and dissolution of lutein. Ternary phase diagram of the SNEDDS was constructed to identify the self-emulsifying regions following
Bhupinder Singh et al.
Drug delivery, 18(8), 599-612 (2011-10-20)
Carvedilol, a widely prescribed cardiovascular drug for hypertension and congestive heart failure, exhibits low and variable bioavailability owing to poor absorption and extensive hepatic first-pass metabolism. The current research work, therefore, entails formulation development of liquid self-nano-emulsifying drug delivery systems
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